Ndjakou Lenta Bruno, Ngouela Silvère, Fekam Boyom Fabrice, Tantangmo Ferdinand, Feuya Tchouya Guy Raymond, Tsamo Etienne, Gut Jiri, Rosenthal Philip Jon, Donald Connolly Joseph
Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon.
Chem Pharm Bull (Tokyo). 2007 Mar;55(3):464-7. doi: 10.1248/cpb.55.464.
Bazouanthrone (1), a new anthrone derivative, has been isolated from the root bark of Harungana madagascariensis, together with known compounds, feruginin A (2), harunganin (3), harunganol A (4), harunganol B (5), friedelan-3-one (6) and betulinic acid (7). The structure of the compound (1) was assigned as 3,5,8,9-tetrahydroxy-2,4,4-tri-(3,3-dimethylallyl)-6-methyl-1-(4H)-anthracenone, by means of spectroscopic analysis. The anti-plasmodial activity of the isolated compounds was evaluated in culture against W2 strain of Plasmodium falciparum. All the compounds were found to be active against the Plasmodium parasites with bazouanthrone (1) showing particular potency (IC50=1.80 microM).
巴祖蒽醌（1）是一种新的蒽醌衍生物，已从马达加斯加哈伦加那树的根皮中分离出来，同时还分离出了已知化合物，铁锈宁A（2）、哈伦加宁（3）、哈伦加醇A（4）、哈伦加醇B（5）、木栓酮（6）和桦木酸（7）。通过光谱分析，化合物（1）的结构被确定为3,5,8,9-四羟基-2,4,4-三-（3,3-二甲基烯丙基）-6-甲基-1-（4H）-蒽醌。对分离得到的化合物在体外对恶性疟原虫W2株的抗疟活性进行了评估。发现所有化合物对疟原虫均有活性，其中巴祖蒽醌（1）表现出特别的效力（IC50 = 1.80微摩尔）。
