Kouam Simeon F, Ngadjui Bonaventure T, Krohn Karsten, Wafo Pascal, Ajaz Asma, Choudhary M Iqbal
Department of Chemistry, Higher Teachers' Training College, University of Yaounde 1, BP 47, Yaounde, Cameroon.
Phytochemistry. 2005 May;66(10):1174-9. doi: 10.1016/j.phytochem.2005.03.022.
Two new prenylated anthronoids, harunmadagascarins A and B, were isolated from the stem bark of Harungana madagascariensis along with six known compounds including two anthronoids: harunganol B and harungin anthrone, one benzophenone: methyl 3-formyl-2,4-dihydroxy-6-methyl benzoate and three pentacyclic triterpenes: friedelin, lupeol and betulinic acid. Harunmadagascarins A and B were characterized as 8,9-dihydroxy-4,4-bis-(3,3-dimethylallyl)-6-methyl-2,3-(2,2-dimethylpyrano)anthrone and 8,9-dihydroxy-4,4,5-tris-(3,3-dimethylallyl)-6-methyl-2,3-(2,2-dimethylpyrano)anthrone, respectively. The structures of these secondary metabolites were determined by spectroscopic means and comparison with the published data. Methyl 3-formyl-2,4-dihydroxy-6-methyl benzoate was isolated for the first time from a plant. Harunmadagascarins A and B, harunganol B and harungin anthrone exhibited significant antioxidant activity.
从马达加斯加哈伦加那树（Harungana madagascariensis）的茎皮中分离出两种新的异戊烯基蒽酮类化合物，哈伦马达加斯加素A和B，以及六种已知化合物，包括两种蒽酮类化合物：哈伦加醇B和哈伦因蒽酮，一种二苯甲酮：3-甲酰基-2,4-二羟基-6-甲基苯甲酸甲酯，以及三种五环三萜类化合物：木栓酮、羽扇豆醇和桦木酸。哈伦马达加斯加素A和B分别被鉴定为8,9-二羟基-4,4-双-(3,3-二甲基烯丙基)-6-甲基-2,3-(2,2-二甲基吡喃)蒽酮和8,9-二羟基-4,4,5-三-(3,3-二甲基烯丙基)-6-甲基-2,3-(2,2-二甲基吡喃)蒽酮。这些次生代谢产物的结构通过光谱手段并与已发表的数据进行比较得以确定。3-甲酰基-2,4-二羟基-6-甲基苯甲酸甲酯首次从植物中分离得到。哈伦马达加斯加素A和B、哈伦加醇B和哈伦因蒽酮表现出显著的抗氧化活性。
