Kouam Simeon F, Khan Shamsun Nahar, Krohn Karsten, Ngadjui Bonaventure T, Kapche Deccaux G W F, Yapna Diane B, Zareem Seema, Moustafa Amal M Y, Choudhary M Iqbal
Department of Chemistry, Higher Teachers' Training College, University of Yaounde 1, BP 47, Yaounde, Cameroon.
J Nat Prod. 2006 Feb;69(2):229-33. doi: 10.1021/np050407n.
One new prenylated 1,4-anthraquinone and three new prenylated anthranols, named kengaquinone (1) and kenganthranols A (2), B (3), and C (4), were isolated from a hexane extract of the stem bark of Harungana madagascariensis. Six known compounds including anthraquinones, anthrones, and xanthones were also isolated and identified. The structures of the new compounds were determined by analysis of spectroscopic data and comparison with data of previously known analogues. Some isolated compounds (3-5, 7-11) were evaluated for their alpha-glucosidase inhibition activity. Compounds 3, 4, 8, and 11 showed significant activity, whereas compounds 7, 9, and 10 were inactive in this test.
从马达加斯加哈伦加那树（Harungana madagascariensis）茎皮的己烷提取物中分离出一种新的异戊烯基化1,4-蒽醌和三种新的异戊烯基化蒽酚，分别命名为肯加醌（1）和肯加蒽酚A（2）、B（3）和C（4）。还分离并鉴定了六种已知化合物，包括蒽醌、蒽酮和呫吨酮。通过光谱数据分析并与先前已知类似物的数据进行比较，确定了新化合物的结构。对一些分离出的化合物（3 - 5、7 - 11）进行了α-葡萄糖苷酶抑制活性评估。化合物3、4、8和11表现出显著活性，而化合物7、9和10在该测试中无活性。
