Mahdi N K, Gany Z H, Sharief M
Department of Microbiology, University of Basra, Iraq.
East Mediterr Health J. 2006 Sep;12(5):679-84.
To investigate the effect of drugs other than metronidazole, 3 non-pregnant women infected with Trichomonas vaginalis were treated with doxycycline, 2 x 200 mg/day for 1 week. Another 3 women were treated with praziquantel, single dose, 40 mg/kg body weight. No therapeutic effect was detected for either drug. In vitro, oxytetracycline led to death of T. vaginalis at a concentration of 15 mg in 0.5 mL medium. Extract of Myrtus communis caused death of T. vaginalis at pH 4.65, but failed to do so at pH 6.00. Extract of Eucalyptus comaldensis (50 mg in 0.1 mL medium) at pH 5.35 caused death of T. vaginalis after 24 hours.
为研究甲硝唑以外的药物的效果，对3名感染阴道毛滴虫的非妊娠妇女用强力霉素进行治疗，每日2次，每次200mg，共1周。另外3名妇女用吡喹酮单剂量治疗，体重每千克40mg。两种药物均未检测到治疗效果。在体外，土霉素在0.5mL培养基中浓度为15mg时可导致阴道毛滴虫死亡。香桃木提取物在pH4.65时可导致阴道毛滴虫死亡，但在pH6.00时则不能。在pH5.35时，薄皮桉提取物（0.1mL培养基中50mg）在24小时后可导致阴道毛滴虫死亡。
