Morrens Manuel, Krabbendam Lydia, Bak Maarten, Delespaul Phillippe, Mengelers Ron, Sabbe Bernard, Hulstijn Wouter, van Os Jim, Myin-Germeys Inez
Collaborative Antwerp Psychiatric Research Institute, Campus Drie Eiken, Antwerp, Belgium.
Soc Psychiatry Psychiatr Epidemiol. 2007 Apr;42(4):284-7. doi: 10.1007/s00127-007-0170-7. Epub 2007 Mar 2.
The aim of the current study was to replicate the finding that cognitive impairments are not or inversely associated with sensitivity to stress in a sample of 25 patients diagnosed with psychotic disorder. The results indicated that impairments in performance on the Trailmaking Test and the Stroop Color Word Test were inversely associated with sensitivity to stress in daily life, whereas impairment in a subtest of the Behavioral Assessment of Dysexecutive Syndrome (BADS) was not associated with stress-sensitivity. The data thus show that in some instances cognitive functioning is not, and in other instances is inversely associated with momentary sensitivity to stress. Cognitive impairment and affective reactivity thus appear to be independent or mutually exclusive mechanisms in psychosis, suggesting competing causal pathways.
本研究的目的是在25名被诊断为精神障碍的患者样本中复制认知障碍与应激敏感性不存在关联或呈负相关的这一发现。结果表明，连线测验和斯特鲁普色词测验的表现受损与日常生活中的应激敏感性呈负相关，而执行功能障碍行为评估（BADS）子测验中的受损与应激敏感性无关。因此，数据表明，在某些情况下认知功能与应激敏感性不存在关联，而在其他情况下则呈负相关。认知障碍和情感反应性在精神病中似乎是独立的或相互排斥的机制，提示存在相互竞争的因果途径。
