年龄依赖性的吸入沙丁胺醇的全身暴露量。
Age dependent systemic exposure to inhaled salbutamol.
作者信息
Bønnelykke Klaus, Jespersen Jakob Jessing, Bisgaard Hans
机构信息
Danish Pediatric Asthma Center; Copenhagen University Hospital, Gentofte, Copenhagen, Denmark.
出版信息
Br J Clin Pharmacol. 2007 Aug;64(2):241-4. doi: 10.1111/j.1365-2125.2007.02868.x. Epub 2007 Mar 1.
Abstract
AIMS
To determine the effect of age on systemic exposure to inhaled salbutamol in children.
METHODS
Fifty-eight asthmatic children, aged 3-16 years, inhaled 400 microg of salbutamol from a pressurized metered dose inhaler with spacer. The 20 min serum profile was analyzed.
RESULTS
Prescribing a dose on a microg kg(-1) basis caused reduced systemic exposure in young children (Y) compared with older children (O) (C(max-microg kg(-1)-adjusted) Y : O ratio (95%CI) = 0.55 (0.47, 0.65)) whereas a fixed nominal dose irrespective of age caused increased exposure in young children (C(max) Y : O ratio (95%CI) = 1.7 (1.3, 2.2)).
CONCLUSIONS
For similar systemic exposure, dosing should be adjusted to age or size but not on a fixed microg kg(-1) basis, which may lead to unnecessary suboptimal dosing.
摘要
目的
确定年龄对儿童吸入沙丁胺醇全身暴露的影响。
方法
58名3至16岁的哮喘儿童使用带储雾罐的压力定量吸入器吸入400微克沙丁胺醇。分析20分钟时的血清情况。
结果
按微克每千克（-1）给药，幼儿（Y）的全身暴露比大龄儿童（O）减少（调整后的最大血药浓度微克每千克（-1）：Y与O的比值（95%置信区间）=0.55（0.47，0.65）），而不考虑年龄的固定标称剂量会使幼儿的暴露增加（最大血药浓度Y与O的比值（95%置信区间）=1.7（1.3，2.2））。
结论
为获得相似的全身暴露，给药应根据年龄或体重进行调整，而不是基于固定的微克每千克（-1），因为这可能导致不必要的次优给药。
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