艾滋病相关持续性全身性淋巴结肿大（PGL）和血小板减少症患者的人类白细胞抗原A、B和DR抗原频率。

HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia.

作者信息

Raffoux C, David V, Couderc L D, Rabian C, Clauvel J P, Seligmann M, Colombani J

出版信息

Tissue Antigens. 1987 Jan;29(1):60-2. doi: 10.1111/j.1399-0039.1987.tb01550.x.

DOI:10.1111/j.1399-0039.1987.tb01550.x

Abstract

HLA-A, B, DR phenotype frequencies were studied in 69 homosexual patients with persistent generalized lymphadenopathy (PGL), in 8 patients with LAV/HTLV III related thrombocytopenic purpura and in 21 homosexual controls. Antigen DR5 was significantly increased in PGL patient groups as compared to controls. Our findings suggest that genetic factors associated with HLA-DR5 antigen may predispose individuals infected by the LAV/HTLV III virus to the occurrence of PGL and/or thrombocytopenia.

摘要

对69例患有持续性全身性淋巴结病（PGL）的同性恋患者、8例与淋巴腺病相关病毒/人嗜T淋巴细胞病毒III型（LAV/HTLV III）相关的血小板减少性紫癜患者以及21名同性恋对照者的人类白细胞抗原-A、B、DR表型频率进行了研究。与对照组相比，PGL患者组中抗原DR5显著增加。我们的研究结果表明，与HLA-DR5抗原相关的遗传因素可能使感染LAV/HTLV III病毒的个体易患PGL和/或血小板减少症。