来自海鞘类拟双瘤海鞘属的氨基醇

Amino alcohols from the ascidian Pseudodistoma sp.

作者信息

Won Tae Hyung, You Minjung, Lee So-Hyoung, Rho Boon Jo, Oh Dong-Chan, Oh Ki-Bong, Shin Jongheon

机构信息

Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.

Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea.

出版信息

Mar Drugs. 2014 Jun 24;12(6):3754-69. doi: 10.3390/md12063754.

DOI:10.3390/md12063754

PMID:24962272

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4071600/

Abstract

Seven new amino alcohol compounds, pseudoaminols A-G (1-7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na+/K+-ATPase.

摘要

从韩国济州岛海岸采集的拟双瘤海鞘（Pseudodistoma sp.）中分离出七种新的氨基醇化合物，即假氨基醇A - G（1 - 7）。通过光谱数据分析和化学转化确定了这些新化合物的结构。其中两种新化合物（6和7）中存在N - 羧甲基，这在氨基醇中是前所未有的。这些化合物中的几种表现出适度的抗菌活性和细胞毒性，以及对Na+/K+-ATP酶的微弱抑制活性。