Matsui Elizabeth C, Eggleston Peyton A, Breysse Patrick N, Rand Cynthia S, Diette Gregory B
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
J Allergy Clin Immunol. 2007 Apr;119(4):910-5. doi: 10.1016/j.jaci.2006.12.663. Epub 2007 Mar 2.
Although mouse allergen exposure is common in inner-city homes, little is known about the relationships between exposure and humoral immune responses to mouse allergen in this population.
To examine relationships between mouse allergen exposure and allergen-specific IgE and IgG responses in inner-city children with asthma.
Inner-city children with asthma underwent skin testing and venipuncture for determination of mouse allergen-specific IgE and IgG levels. Settled dust samples were collected from their homes for allergen analysis.
The study population (n = 112) was predominantly African American (92%) with a mean age of 4.4 years. The prevalence rate of mouse sensitization was 25% and did not consistently increase with increasing Mus m 1 levels. Instead, the prevalence rate was lowest among those exposed to <2 microg/g, increased among those exposed to 2-7.9 microg/g and 8-29.9 microg/g, and then decreased among participants exposed to >29.9 microg/g (14%, 20%, 40%, and 28%, respectively). Similarly, the prevalence rates of mouse allergen-specific IgG and IgG(4) did not increase across increasing exposure categories. Mouse allergen-specific IgG and IgG(4) were strongly associated with IgE sensitization (odds ratios [95% CI], 82.8 [20.5-334.4] and 50.4 [14.0-181.7], respectively).
High-level exposure to mouse allergen in children may be associated with attenuated humoral responses of all isotypes rather than selective attenuation of IgE.
Protection against allergic sensitization by high-dose allergen exposure may not be mediated by preferential production of IgG over IgE.
尽管在市中心的家庭中，接触小鼠过敏原的情况很常见，但对于该人群中接触小鼠过敏原与体液免疫反应之间的关系却知之甚少。
研究市中心哮喘儿童接触小鼠过敏原与过敏原特异性IgE和IgG反应之间的关系。
对市中心哮喘儿童进行皮肤试验和静脉穿刺，以测定小鼠过敏原特异性IgE和IgG水平。从他们家中收集 settled 灰尘样本进行过敏原分析。
研究人群（n = 112）主要为非裔美国人（92%），平均年龄4.4岁。小鼠致敏的患病率为25%，且并不随Mus m 1水平的升高而持续增加。相反，在接触量<2微克/克的人群中患病率最低，在接触量为2 - 7.9微克/克和8 - 29.9微克/克的人群中患病率增加，而在接触量>29.9微克/克的参与者中患病率下降（分别为14%、20%、40%和28%）。同样，小鼠过敏原特异性IgG和IgG(4)的患病率在不同接触类别中也没有增加。小鼠过敏原特异性IgG和IgG(4)与IgE致敏密切相关（优势比[95%可信区间]分别为82.8[20.5 - 334.4]和50.4[14.0 - 181.7]）。
儿童高水平接触小鼠过敏原可能与所有同种型的体液反应减弱有关，而非IgE的选择性减弱。
高剂量过敏原暴露对过敏性致敏的保护作用可能并非由IgG相对于IgE的优先产生介导。
