The Johns Hopkins Hospital, CMSC 1102, 600 N. Wolfe Street, Baltimore, MD, 21287, USA,
Curr Allergy Asthma Rep. 2013 Dec;13(6):681-6. doi: 10.1007/s11882-013-0378-4.
Although rodent allergy has long been recognized as an occupational disease, it has only been in the past decade that it has been recognized as a community-based disease that affects children. Most homes in the US have detectable mouse allergen, but the concentrations in inner-city homes are orders of magnitude higher than those found in suburban homes. Home mouse allergen exposure has been linked to sensitization to mouse, and children with asthma who are both sensitized and exposed to high mouse allergen concentrations at home are at greater risk for symptoms, exacerbations and reduced lung function. Rat allergen is found primarily in inner-city homes and has also been linked to asthma morbidity among sensitized children. The objective of this review is to summarize the scientific literature on rodents and their allergens, the effects of exposure to these allergens on allergic respiratory disease, and to make recommendations, based on this evidence base, for the evaluation and management of mouse allergy in the pediatric population.
尽管啮齿动物过敏早已被认为是一种职业病，但直到过去十年，它才被认为是一种影响儿童的社区性疾病。美国大多数家庭都能检测到老鼠过敏原，但城市内家庭的浓度比郊区家庭高几个数量级。家庭老鼠过敏原暴露与对老鼠的致敏有关，而在家中既致敏又暴露于高浓度老鼠过敏原的哮喘儿童发生症状、加重和肺功能下降的风险更大。大鼠过敏原主要存在于城市内家庭中，也与致敏儿童的哮喘发病率有关。本综述的目的是总结关于啮齿动物及其过敏原的科学文献，以及接触这些过敏原对过敏性呼吸道疾病的影响，并根据这一证据基础，就儿科人群中老鼠过敏的评估和管理提出建议。
