Matsui Elizabeth C, Wood Robert A, Rand Cynthia, Kanchanaraksa Sukon, Swartz Lee, Eggleston Peyton A
Department of Pediatrics, Johns Hopkins University, Johns Hopkins Hospital, CMSC 1102, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
J Allergy Clin Immunol. 2004 May;113(5):910-5. doi: 10.1016/j.jaci.2004.02.034.
Exposure to mouse allergen is prevalent in inner-city homes and is associated with an increased risk of mouse skin test sensitivity in inner-city children with asthma.
To determine the distribution of mouse allergen and its relationship to mouse skin test sensitivity in a primarily suburban, middle-class population of asthmatic children.
Children with asthma, 6 to 17 years old, were recruited from 3 pediatric practices located in counties surrounding the city of Baltimore and from 1 practice located within the city limits. Participants underwent skin prick testing and completed a baseline questionnaire. Their homes were inspected, and settled dust samples were collected for allergen analysis.
Two hundred fifty-seven of 335 (76.7%) participants resided outside the city, and 53.7% had annual incomes >$50,000. Mouse allergen was detected in 74.9% of bedrooms, and 13.1% were sensitized to mouse. Lower maternal education (odds ratio [OR], 2.17; 95% CI, 1.28-3.67), city residence (OR, 5.39; 95% CI, 2.23-13.02), and higher bedroom cockroach allergen levels (OR, 9.61; 95% CI, 1.17-79.03) were independent predictors of high bedroom mouse allergen. The risk of mouse skin test sensitivity increased with increasing bedroom Mus m 1 exposure (OR, 1.43; 95% CI, 1.04-1.96, with each increase in quartile), and dog skin test sensitivity was a strong independent predictor of mouse skin test sensitivity (OR, 7.23; 95% CI, 3.03-17.22).
Mouse allergen exposure is common among suburban, middle-class asthmatic children. Increasing bedroom levels of Mus m 1 and dog skin test sensitivity are risk factors for mouse skin test sensitivity.
在市中心家庭中，接触小鼠变应原的情况很普遍，且与市中心哮喘儿童小鼠皮肤试验敏感性增加的风险相关。
确定在主要为郊区的中产阶级哮喘儿童人群中小鼠变应原的分布及其与小鼠皮肤试验敏感性的关系。
招募了6至17岁的哮喘儿童，他们来自巴尔的摩市周边各县的3家儿科诊所和市内的1家诊所。参与者接受了皮肤点刺试验并完成了一份基线问卷。对他们的家进行了检查，并收集了沉降灰尘样本进行变应原分析。
335名参与者中有257名（76.7%）居住在城外，53.7%的家庭年收入超过5万美元。在74.9%的卧室中检测到小鼠变应原，13.1%的人对小鼠致敏。母亲教育程度较低（优势比[OR]，2.17；95%置信区间[CI]，1.28 - 3.67）、居住在市内（OR，5.39；95% CI，2.23 - 13.02）以及卧室蟑螂变应原水平较高（OR，9.61；95% CI，1.17 - 79.03）是卧室小鼠变应原水平高的独立预测因素。随着卧室中Mus m 1暴露量增加，小鼠皮肤试验敏感性风险增加（OR，1.43；95% CI，1.04 - 1.96，每增加一个四分位数），并且犬皮肤试验敏感性是小鼠皮肤试验敏感性的一个强有力的独立预测因素（OR，7.23；95% CI，3.03 - 17.22）。
在郊区中产阶级哮喘儿童中，接触小鼠变应原的情况很常见。卧室中Mus m 1水平升高和犬皮肤试验敏感性是小鼠皮肤试验敏感性的危险因素。
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