Mathers Alicia R, Larregina Adriana T
Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Immunol Res. 2006;36(1-3):127-36. doi: 10.1385/IR:36:1:127.
The skin functions as an important pro-inflammatory and immune organ. Accordingly, the epidermis and dermis are highly populated by dendritic cells (DC), which are potent antigen-presenting cells (APC) with important immunostimulatory and migratory activities. Whereas the biological characteristics and immunological functions of epidermal DC known as Langernahs cells (LC) have been the focus of intense research in the past, less is known regarding their dermal counterparts named dermal dendritic cells (DDC). Although it has been widely accepted that LC are the more relevant skin-resident APC, recent experimental evidence challenges this concept and proposes a different role for these important cell populations. In this article we compile recent scientific advances regarding the function of different skin-resident DC and we try to reconcile the new observations with the previously established paradigm.
皮肤作为一个重要的促炎和免疫器官发挥作用。因此，表皮和真皮中富含树突状细胞（DC），它们是具有重要免疫刺激和迁移活性的强效抗原呈递细胞（APC）。虽然过去被称为朗格汉斯细胞（LC）的表皮DC的生物学特性和免疫功能一直是深入研究的重点，但对于其真皮对应物即真皮树突状细胞（DDC）的了解却较少。尽管人们普遍认为LC是更相关的驻留皮肤APC，但最近的实验证据对这一概念提出了挑战，并为这些重要细胞群体提出了不同的作用。在本文中，我们汇总了关于不同驻留皮肤DC功能的最新科学进展，并尝试将新的观察结果与先前确立的范式相协调。
