Brawner D L, Anderson G L, Yuen K Y
Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104-2092.
J Clin Microbiol. 1992 Jan;30(1):149-53. doi: 10.1128/jcm.30.1.149-153.1992.
Blood culture isolates of Candida albicans were collected from 102 patients in Seattle, Wash., hospitals (n = 77) and Hong Kong (n = 25). The patients were classified by immune status into two groups. Group I patients were severely immunosppression, and group II patients had underlying risk factors for candidemia but no underlying immunosuppression. Serotyping by Hasenclever tube agglutination was done. In the Seattle area, the odds of fungemia with type B C. albicans were 3.62 times greater than the odds of type B fungemia in group II patients. Although the odds ratio could not be computed for Hong Kong patients, the direction of the relationship in this population was consistent with the data on Seattle patients. Despite the magnitude of the odds ratios, the relative prevalence of type B over type A in group I compared with group II was not significant when analyzed separately by region, probably because of relatively low numbers of isolates in group II. Accepting that the effect of immune status on serotype is equivalent across regions but presupposing that a regional effect on type B prevalence exists, the pooled odds for fungemia with serotype B in group I patients are increased 5.4-fold over those of group II patients. Logistic regression analysis controlling for region gave similar results.
从华盛顿州西雅图市的医院（n = 77）和香港（n = 25）的102名患者中收集了白色念珠菌的血培养分离株。患者按免疫状态分为两组。第一组患者为严重免疫抑制，第二组患者有念珠菌血症的潜在危险因素但无潜在免疫抑制。采用哈森克莱弗试管凝集法进行血清分型。在西雅图地区，B型白色念珠菌引起真菌血症的几率比第二组患者中B型真菌血症的几率高3.62倍。虽然无法计算香港患者的比值比，但该人群中这种关系的方向与西雅图患者的数据一致。尽管比值比的幅度较大，但按地区分别分析时，第一组中B型相对于A型的相对流行率与第二组相比并不显著，可能是因为第二组中的分离株数量相对较少。假设免疫状态对血清型的影响在各地区是相同的，但预先假定存在对B型流行率的地区性影响，那么第一组患者中B型血清型真菌血症的合并几率比第二组患者增加了5.4倍。控制地区因素的逻辑回归分析得出了类似的结果。
