Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan 333, Taiwan.
Int J Mol Sci. 2019 May 24;20(10):2558. doi: 10.3390/ijms20102558.
Natural products or herbs can be used as an effective therapy for treating psoriasis, an autoimmune skin disease that involves keratinocyte overproliferation. It has been demonstrated that phytomedicine, which is used for psoriasis patients, provides some advantages, including natural sources, a lower risk of adverse effects, and the avoidance of dissatisfaction with conventional therapy. The herbal products' structural diversity and multiple mechanisms of action have enabled the synergistic activity to mitigate psoriasis. In recent years, the concept of using natural products as antiproliferative agents in psoriasis treatment has attracted increasing attention in basic and clinical investigations. This review highlights the development of an apoptotic or antiproliferatic strategy for natural-product management in the treatment of psoriasis. We systematically introduce the concepts and molecular mechanisms of keratinocyte-proliferation inhibition by crude extracts or natural compounds that were isolated from natural resources, especially plants. Most of these studies focus on evaluation through an in vitro keratinocyte model and an in vivo psoriasis-like animal model. Topical delivery is the major route for the in vivo or clinical administration of these natural products. The potential use of antiproliferative phytomedicine on hyperproliferative keratinocytes suggests a way forward for generating advances in the field of psoriasis therapy.
天然产物或草药可作为治疗银屑病的有效疗法，银屑病是一种涉及角质形成细胞过度增殖的自身免疫性皮肤病。已经证明，用于银屑病患者的植物药具有一些优点，包括天然来源、不良反应风险较低以及避免对传统疗法的不满。草药产品的结构多样性和多种作用机制使协同作用能够缓解银屑病。近年来，将天然产物用作银屑病治疗中的抗增殖剂的概念在基础和临床研究中引起了越来越多的关注。本综述强调了将天然产物作为治疗银屑病的凋亡或抗增殖策略的发展。我们系统地介绍了从天然资源（尤其是植物）中分离出的粗提取物或天然化合物抑制角质形成细胞增殖的概念和分子机制。这些研究大多集中在体外角质形成细胞模型和银屑病样动物模型中的评估。这些天然产物的体内或临床给药的主要途径是局部给药。抗增殖植物药对过度增殖的角质形成细胞的潜在用途为银屑病治疗领域的进展提供了一种方法。
