助力无翅蛋白展翅：WNT蛋白的分泌方式
Helping Wingless take flight: how WNT proteins are secreted.
作者信息
Hausmann George, Bänziger Carla, Basler Konrad
机构信息
Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
出版信息
Nat Rev Mol Cell Biol. 2007 Apr;8(4):331-6. doi: 10.1038/nrm2141. Epub 2007 Mar 7.
How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.
功能性WNT蛋白是如何产生的以及它们的分泌是如何被调控的，正成为WNT信号传导领域的一个焦点。最近，脂蛋白颗粒、WNT脂质修饰、保守的跨膜蛋白Wntless（WLS；也称为EVI和SRT）以及逆转录复合物已被证明与WNT分泌有关。我们的目标是综合这些新发现，以探讨WNT分泌背后的机制。
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