Hawasawi Z M, Nabi G, Al Magamci M S, Awad K S
Maternity and Children's Hospital, Madina, Saudi Arabia.
Ann Saudi Med. 1998 Jul-Aug;18(4):293-5. doi: 10.5144/0256-4947.1998.293.
Sickle cell disease (SCD) is a common disease in Saudi Arabia, with a high prevalence in the Eastern and Southern regions. This study reports on 53 cases of SCD encountered in the Madina area.
In a retrospective study of 6000 pediatric patients, 53 children (0.88%) with sickle cell disease were admitted in the Maternity and Childrenâs Hospital at Madina, between November 1990 and October 1991. Of these, 39 patients (73.58%) were Saudis and 14 (26.41%) were non-Saudis.
Thirty-six patients were homozygous SS and 17 were sickle thalassemic. The main causes of admission were vaso-occlusive crisis (77.35%), infection (67.92%), acute chest syndrome (22.64%), anemia (12.6%), and cerebrovascular accident (9.43%). The lowest and highest age groups recorded in this study were six months and 12 years, respectively. About 70% of the patients are still being followed up, and none of the patients has died.
. This disease is one of the major causes of morbidity in this region of Saudi Arabia. Measures required include neonatal screening programs for the early detection of the disease, as well as research into new drugs to counter the disease.
镰状细胞病（SCD）在沙特阿拉伯是一种常见疾病，在东部和南部地区患病率很高。本研究报告了麦地那地区遇到的53例镰状细胞病病例。
在一项对6000名儿科患者的回顾性研究中，1990年11月至1991年10月期间，有53名（0.88%）镰状细胞病患儿入住麦地那妇幼医院。其中，39例（73.58%）为沙特人，14例（26.41%）为非沙特人。
36例为纯合子SS，17例为镰状细胞贫血症。入院的主要原因是血管闭塞性危机（77.35%）、感染（67.92%）、急性胸综合征（22.64%）、贫血（12.6%）和脑血管意外（9.43%）。本研究记录的最低和最高年龄组分别为6个月和12岁。约70%的患者仍在接受随访，且无患者死亡。
该疾病是沙特阿拉伯该地区发病的主要原因之一。所需措施包括开展新生儿筛查项目以早期发现该疾病，以及研发治疗该疾病的新药。
