Seckin Yuksel, Harputluoglu Murat M M, Batcioglu Kadir, Karincaoglu Melih, Yildirim Bulent, Oner Ramazan I, Uyumlu Burcin, Aydogdu Nurettin, Hilmioglu Fatih
Department of Gastroenterology and Biochemistry, Inonu University, Turgut Ozal Tip Merkezi, 44000, Malatya, Turkey.
Dig Dis Sci. 2007 May;52(5):1154-8. doi: 10.1007/s10620-006-9139-8. Epub 2007 Mar 8.
Gastric mucosal lesions are very common in portal hypertension and cirrhosis. The aim of this study was to assess for oxidative gastric tissue damage in cirrhosis and evaluate relations with portal hypertension and cirrhosis parameters. The study included 30 patients with cirrhosis and 30 controls. Each patient's history, physical examination, and laboratory findings were recorded, and multiple biopsies of the gastric antrum were obtained at endoscopy. A set of antral biopsies was also collected from each control subject. Each tissue specimen was analyzed for levels of glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) activity and level of malondialdehyde (MDA). Patients' gastric GPX, SOD, and CAT levels were significantly lower, and MDA levels were higher, than in the control group. The GPX activity level in the specimens was moderately negatively correlated with portal vein diameter (P<0.05, r=-0.45) and spleen length (P<0.05, r=-0.45). In this study gastric tissue oxidative markers showed that antral oxidative factors worsen in cirrhosis. Oxidative stress may not be a clinical condition but it obviously shows gastric tissue damage and may explain many patients' gastric lesions and hemorrhage.
胃黏膜病变在门静脉高压症和肝硬化中非常常见。本研究的目的是评估肝硬化患者胃组织的氧化损伤情况，并评估其与门静脉高压症及肝硬化参数之间的关系。该研究纳入了30例肝硬化患者和30名对照者。记录了每位患者的病史、体格检查和实验室检查结果，并在内镜检查时获取胃窦的多处活检组织。同时也从每位对照者身上采集了一组胃窦活检组织。对每个组织样本分析谷胱甘肽过氧化物酶（GPX）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性水平以及丙二醛（MDA）的水平。患者的胃GPX、SOD和CAT水平显著低于对照组，而MDA水平则高于对照组。样本中的GPX活性水平与门静脉直径（P<0.05，r=-0.45）和脾脏长度（P<0.05，r=-0.45）呈中度负相关。在本研究中，胃组织氧化标志物显示肝硬化患者胃窦氧化因子情况恶化。氧化应激可能不是一种临床病症，但它明显显示出胃组织损伤，并且可能解释许多患者的胃部病变和出血情况。
