Wang Yiting, McCullough Marjorie L, Stevens Victoria L, Rodriguez Carmen, Jacobs Eric J, Teras Lauren R, Pavluck Alexandre L, Thun Michael J, Calle Eugenia E
Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, Georgia, GA 30329-4251, USA.
Anticancer Res. 2007 Jan-Feb;27(1B):589-93.
Accumulating evidence suggests that energy regulation, particularly insulin resistance, may influence breast cancer risk.
The associations between single nucleotide polymorphisms (SNPs) in energy regulation candidate genes and postmenopausal breast cancer risk were evaluated. Conditional logistic regression was run on 488 matched case-control pairs from the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. The studied SNPs were INS+1127 PstI (rs3842752), INSR H1085H (rs1799817) and PPARy Prol2Ala (rs1801282).
A significantly lower breast cancer risk was found among women homozygous for the T allele of INSR H1085H. A marginally significant increased risk of breast cancer was observed among women homozygous for the Ala allele of PPARgamma Pro12Ala. No significant association was observed between INS+ 1127 PstI and breast cancer risk.
Our results suggest that polymorphisms in these energy regulation candidate genes may be associated with risk of breast cancer, but replication in larger studies is needed.
越来越多的证据表明，能量调节，尤其是胰岛素抵抗，可能会影响乳腺癌风险。
评估能量调节候选基因中的单核苷酸多态性（SNP）与绝经后乳腺癌风险之间的关联。对美国癌症协会癌症预防研究II营养队列中的488对匹配病例对照进行条件逻辑回归分析。研究的SNP包括胰岛素基因+1127 PstI（rs3842752）、胰岛素受体基因H1085H（rs1799817）和过氧化物酶体增殖物激活受体γ基因Pro12Ala（rs1801282）。
胰岛素受体基因H1085H的T等位基因纯合女性患乳腺癌的风险显著降低。过氧化物酶体增殖物激活受体γ基因Pro12Ala的Ala等位基因纯合女性患乳腺癌的风险略有增加。胰岛素基因+1127 PstI与乳腺癌风险之间未观察到显著关联。
我们的结果表明，这些能量调节候选基因中的多态性可能与乳腺癌风险相关，但需要在更大规模的研究中进行验证。
