多肌炎和皮肌炎中的磷-31磁共振波谱分析。运动期间能量利用的改变。
P-31 magnetic resonance spectroscopy in polymyositis and dermatomyositis. Altered energy utilization during exercise.
作者信息
Newman E D, Kurland R J
机构信息
Department of Rheumatology, Geisinger Medical Center, Danville, Pennsylvania 17822.
出版信息
Arthritis Rheum. 1992 Feb;35(2):199-203. doi: 10.1002/art.1780350212.
OBJECTIVE
To explore alterations in energy utilization as a potential etiology for weakness in polymyositis and dermatomyositis (PM/DM).
METHODS
P-31 magnetic resonance spectroscopy studies were performed in patients with acute and treated PM/DM and in normal controls, at rest and with exercise.
RESULTS
Patients with acute and treated PM/DM showed increased ratios of inorganic phosphate to phosphocreatine (PCr) during exercise, with loss of ATP disproportional to loss of PCr.
CONCLUSION
This study demonstrates changes in energy utilization in PM/DM, thus supporting the notion of a metabolic etiology for the weakness associated with these diseases.
目的
探讨能量利用的改变作为多发性肌炎和皮肌炎（PM/DM）肌无力的潜在病因。
方法
对急性及经治疗的PM/DM患者和正常对照者在静息和运动状态下进行³¹P磁共振波谱研究。
结果
急性及经治疗的PM/DM患者在运动期间无机磷酸盐与磷酸肌酸（PCr）的比率增加，ATP的消耗与PCr的消耗不成比例。
结论
本研究证明了PM/DM中能量利用的变化，从而支持了与这些疾病相关的肌无力的代谢病因学观点。
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