Ferraris R, Galatola G, Barlotta A, Pellerito R, Fracchia M, Cottino F, de la Pierre M
Department of Gastroenterology and Nuclear Medicine Service, Ospedale Mauriziano Umberto I, Turin, Italy.
Dig Dis Sci. 1992 Feb;37(2):225-32. doi: 10.1007/BF01308176.
The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predictive value, and 78% negative predictive value at the optimal cutoff level of 2.0 days; lower--but not significantly different--figures were observed for [75Se]HCAT total abdominal retention four and seven days after isotope administration, at the optimal cutoff levels of 40% and 22%, respectively. [75Se]HCAT T1/2 was then evaluated in 60 patients with various intestinal diseases. Sixty-nine percent (9/13) of patients with diarrhea of obscure origin showed abnormal [75Se]HCAT T1/2. Bile acid malabsorption using [75Se]HCAT can be investigated by the noninvasive measurement of its enterohepatic T1/2 and may play a pathogenetic role in patients with diarrhea of obscure origin.
已在58名受试者中，针对两种不同的闪烁扫描技术评估了使用[75硒] - 对氨基马尿酸（[75Se]HCAT）检测回肠末端功能障碍的诊断价值。通过每日胆囊闪烁扫描测量肠肝循环中[75硒] - 对氨基马尿酸（[75Se]HCAT）的半衰期（T1/2），在最佳临界值为2.0天时，显示出78%的灵敏度、96%的特异性、96%的阳性预测值和78%的阴性预测值；在同位素给药后第4天和第7天，[75硒] - 对氨基马尿酸（[75Se]HCAT）全腹滞留的相应数值较低，但无显著差异，最佳临界值分别为40%和22%。随后在60例患有各种肠道疾病的患者中评估了[75硒] - 对氨基马尿酸（[75Se]HCAT）的半衰期（T1/2）。69%（9/13）不明原因腹泻患者的[75硒] - 对氨基马尿酸（[75Se]HCAT）半衰期（T1/2）异常。使用[75硒] - 对氨基马尿酸（[75Se]HCAT）对胆汁酸吸收不良的情况可通过对其肠肝循环半衰期（T1/2）进行非侵入性测量来研究，并且可能在不明原因腹泻患者中起致病作用。
