Ferraris R, Colombatti G, Fiorentini M T, Carosso R, Arossa W, De La Pierre M
Dig Dis Sci. 1983 Feb;28(2):129-36. doi: 10.1007/BF01315142.
Total serum bile acids measured by enzymatic fluorometry and routine liver function tests were determined in a large population including 97 healthy subjects, 138 patients free of hepatobiliary diseases but affected by other diseases, and 344 patients with mild or severe hepatobiliary diseases. In order to define the diagnostic value and some operational characteristics of serum bile acids, sensitivity, specificity, and several predictive value tables for increasing cutoff levels of serum bile acids were calculated by means of a computer program. Serum bile acids and aspartate aminotransferase were found to be similar in sensitivity, specificity, and predictive value. Serum aspartate aminotransferase was found to be more suitable than serum bile acids in detecting mild hepatobiliary diseases, whereas serum bile acids were more sensitive than routine liver tests in the evaluation of severe hepatobiliary diseases. In view of its ability to detect severe hepatobiliary diseases, serum bile acids test may play a decisive role in clinical practice (eg, decision to perform a liver biopsy).
采用酶促荧光法测定了包括97名健康受试者、138名无肝胆疾病但患有其他疾病的患者以及344名患有轻度或重度肝胆疾病的患者在内的大量人群的血清总胆汁酸，并进行了常规肝功能检查。为了确定血清胆汁酸的诊断价值和一些操作特征，通过计算机程序计算了血清胆汁酸升高临界值的敏感性、特异性和几个预测值表。发现血清胆汁酸和天冬氨酸转氨酶在敏感性、特异性和预测值方面相似。发现血清天冬氨酸转氨酶在检测轻度肝胆疾病方面比血清胆汁酸更合适，而血清胆汁酸在评估重度肝胆疾病方面比常规肝功能检查更敏感。鉴于血清胆汁酸检测重度肝胆疾病的能力，其在临床实践中（如决定是否进行肝活检）可能起决定性作用。
