Miyazawa I, Nakashima I, Petzold A, Fujihara K, Sato S, Itoyama Y
Department of Neurology, Tohoku University School of Medicine, Seiryo-machi, Aoba-ku, Sendai, Japan.
Neurology. 2007 Mar 13;68(11):865-7. doi: 10.1212/01.wnl.0000256820.26489.17.
The neurofilament heavy chain (NfHSMI35), a biomarker of axonal damage in the CSF, was measured in patients with neuromyelitis optica (NMO) and multiple sclerosis (MS). Significantly high CSF NfHSMI35 levels (>0.73 ng/mL) were found in 6 of 24 (25%) of the patients with NMO but none of the patients with MS (0/24). This finding suggests that axonal damage is more severe in NMO than in MS.
在视神经脊髓炎（NMO）和多发性硬化症（MS）患者中，检测了作为脑脊液中轴突损伤生物标志物的神经丝重链（NfHSMI35）。在24例NMO患者中有6例（25%）脑脊液NfHSMI35水平显著升高（>0.73 ng/mL），而24例MS患者中无一例升高（0/24）。这一发现表明，NMO中的轴突损伤比MS更严重。
