Bullitt Elizabeth, Lin Nancy U, Ewend Matthew G, Zeng Donglin, Winer Eric P, Carey Lisa A, Smith J Keith
CASILab, CB # 7062, University of North Carolina, Chapel Hill, NC 27599, USA.
Med Image Comput Comput Assist Interv. 2006;9(Pt 2):561-8. doi: 10.1007/11866763_69.
No current non-invasive method is capable of assessing the efficacy of brain tumor therapy early during treatment. We outline an approach that evaluates tumor activity via statistical analysis of vessel shape using vessels segmented from MRA. This report is the first to describe the changes in vessel shape that occur during treatment of metastatic brain tumors as assessed by sequential MRA. In this preliminary study of 16 patients undergoing treatment for metastatic breast cancer we conclude that vessel shape may predict tumor response several months in advance of traditional methods.
目前尚无任何非侵入性方法能够在脑肿瘤治疗早期评估其疗效。我们概述了一种方法，即通过对从磁共振血管造影（MRA）中分割出的血管进行形状统计分析来评估肿瘤活性。本报告首次描述了通过连续MRA评估转移性脑肿瘤治疗期间血管形状的变化。在这项对16例接受转移性乳腺癌治疗患者的初步研究中，我们得出结论，血管形状可能比传统方法提前数月预测肿瘤反应。
