验证三种非侵入性实验室指标以预测沙特阿拉伯慢性丙型肝炎患者的显著纤维化和肝硬化
Validation of three noninvasive laboratory variables to predict significant fibrosis and cirrhosis in patients with chronic hepatitis C in Saudi Arabia.
作者信息
Abdo Ayman A, Al Swat Khalid, Azzam Nahla, Ahmed Shaffi, Al Faleh Faleh
机构信息
Abdo College of Medicine, King Saud University P.O. Bob 2925(59) Riyadh 11461, Saudi Arabia.
出版信息
Ann Saudi Med. 2007 Mar-Apr;27(2):89-93. doi: 10.5144/0256-4947.2007.89.
BACKGROUND
We tested the clinical utility of the platelet count, the aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio, and the AST to platelet ratio index (APRI) score in predicting the presence or absence of advanced fibrosis and cirrhosis in patients with chronic hepatitis C in Saudi Arabia.
METHODS
Liver biopsy procedures performed on chronic hepatitis C patients in our gastroenterology unit at King Khalid University Hospital were traced from records between the years 1998 to 2003. The hospital computer database was then accessed and detailed laboratory parameters obtained. By plotting receiver operating characteristic curves (ROC), three selected models (platelet count, AST/ALT ratio, and the APRI score was the one associated with the highest area under the curve (AUC)=0.812 (95% CI, 0.756-0.868) on the ROC curves, compared to the platelet count and AST/ALT ratio, which yielded an AUC of 0.783 (0.711-0.855) and 0.716 (0.642-0.789), respectively.
CONCLUSION
The APRI score seemed to be the best predictive variable for the presence or absence of advanced fibrosis in Saudi hepatitis C patients.
背景
我们测试了血小板计数、天冬氨酸转氨酶/丙氨酸转氨酶（AST/ALT）比值以及AST与血小板比值指数（APRI）评分在预测沙特阿拉伯慢性丙型肝炎患者是否存在晚期肝纤维化和肝硬化方面的临床效用。
方法
追溯了1998年至2003年间在我们位于哈立德国王大学医院胃肠病科对慢性丙型肝炎患者进行的肝活检程序。然后访问医院计算机数据库并获取详细的实验室参数。通过绘制受试者工作特征曲线（ROC），三个选定模型（血小板计数、AST/ALT比值和APRI评分）中，APRI评分在ROC曲线上的曲线下面积（AUC）最高，为0.812（95%可信区间，0.756 - 0.868），相比之下，血小板计数和AST/ALT比值的AUC分别为0.783（0.711 - 0.855）和0.716（0.642 - 0.789）。
结论
APRI评分似乎是沙特丙型肝炎患者是否存在晚期肝纤维化的最佳预测变量。
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