Beversdorf David Q, Ferguson Jennifer L W, Hillier Ashleigh, Sharma Umesh K, Nagaraja Haikady N, Bornstein Robert A, Scharre Douglas W
Department of Neurology, The Ohio State University, Columbus, OH, USA.
Cogn Behav Neurol. 2007 Mar;20(1):44-7. doi: 10.1097/WNN.0b013e31802e5101.
It is important to determine which patients with mild cognitive impairment (MCI) are at risk for progression to dementia. The presence of mild impairments not restricted to the domain of memory may suggest such progression. Our goal is to determine how well a visuospatial problem solving task assessing the cumulative burden of frontal and posterior damage differentiates MCI patients from matched controls.
Twenty-six patients with MCI [Clinical Dementia Rating (CDR) score of 0.5] and mini-mental state examination (MMSE) scores of at least 24/30, were compared with 20 age and education level matched controls without cognitive impairment. All patients were given the MMSE, Hopkins Verbal Learning Test (HVLT), Boston Naming Test (BNT), Rey Complex Figures copying (RCF), anagrams, and visuospatial problem solving battery (VPS). The VPS is a complex problem solving task, which we predicted would better discriminate patient groups than the relatively simpler tasks.
Differences existed between groups on most tasks, but logistic regression revealed that the VPS discriminated the 2 groups better than the other nonmemory cognitive tests.
The VPS, a problem solving task assessing the cumulative burden of frontal and posterior damage is more sensitive for detecting nonmemory impairments in MCI than other tasks. Future research will be needed to determine if impairment in the VPS is a sensitive predictor of progression to dementia or treatment response.
确定哪些轻度认知障碍（MCI）患者有进展为痴呆症的风险至关重要。存在不限于记忆领域的轻度损害可能提示这种进展。我们的目标是确定一项评估额叶和后部损伤累积负担的视觉空间问题解决任务在区分MCI患者与匹配对照组方面的效果如何。
将26例MCI患者[临床痴呆评定量表（CDR）评分为0.5]且简易精神状态检查表（MMSE）得分至少为24/30，与20名年龄和教育水平匹配的无认知障碍对照组进行比较。所有患者均接受MMSE、霍普金斯言语学习测验（HVLT）、波士顿命名测验（BNT）、雷氏复杂图形临摹（RCF）、字谜游戏以及视觉空间问题解决成套测验（VPS）。VPS是一项复杂的问题解决任务，我们预计它比相对简单的任务能更好地区分患者组。
在大多数任务上两组之间存在差异，但逻辑回归显示VPS比其他非记忆认知测试能更好地区分这两组。
VPS这项评估额叶和后部损伤累积负担的问题解决任务，在检测MCI患者的非记忆损害方面比其他任务更敏感。未来需要开展研究以确定VPS中的损害是否是进展为痴呆症或治疗反应的敏感预测指标。
