Abubakar I, Crofts J P, Gelb D, Story A, Andrews N, Watson J M
Respiratory Diseases Department, Centre for Infections, Health Protection Agency, London, UK.
Epidemiol Infect. 2008 Jan;136(1):122-7. doi: 10.1017/S0950268807008333. Epub 2007 Mar 15.
The purpose of this study was to compare the occurrence of tuberculosis (TB) and the outcome of treatment between TB patients living in urban and rural areas. Cases of TB reported from 2001 to 2003 in England and Wales were assigned to a rural or urban area classification. The outcome of interest, non-completion of treatment, was investigated to determine the odds ratio for urban vs. rural residence. The effects of age, sex, ethnicity, place of birth, time since arrival in the United Kingdom, disease site, isoniazid resistance and previous diagnosis were adjusted for by multivariable logistic regression. Crude odds ratios showed a significantly higher level of treatment non-completion in rural areas. These results became non-significant (OR 1.02, 95% CI 0.83-1.26, P=0.82) after adjusting for the confounding effects of ethnic group and age. In England and Wales residence in a rural location is not an independent determinant of TB treatment outcome failure.
本研究的目的是比较生活在城市和农村地区的结核病（TB）患者中结核病的发生率以及治疗结果。将2001年至2003年在英格兰和威尔士报告的结核病病例分为农村或城市地区类别。对感兴趣的结果，即治疗未完成情况进行调查，以确定城市与农村居民的比值比。通过多变量逻辑回归对年龄、性别、种族、出生地、抵达英国后的时间、疾病部位、异烟肼耐药性和既往诊断的影响进行了调整。粗比值比显示农村地区治疗未完成的水平显著更高。在调整了种族和年龄的混杂效应后，这些结果变得不显著（比值比1.02，95%置信区间0.83 - 1.26，P = 0.82）。在英格兰和威尔士，居住在农村地区并非结核病治疗结果失败的独立决定因素。
