Chittajallu R S, Dorrian C A, Ardill J E, McColl K E
University Dept. of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, U.K.
Scand J Gastroenterol. 1992;27(1):20-4. doi: 10.3109/00365529209011160.
Duodenal ulcer patients have increased serum pepsinogen I (PGI) concentrations and an increased prevalence of Helicobacter pylori infection. We have examined the effect of eradicating the infection on PGI. In 12 duodenal ulcer patients in whom H. pylori was successfully eradicated, the median basal PGI was 90 ng/ml (range, 37-252) before treatment and fell to 74 ng/ml (28-197) 1 month after treatment (p less than 0.01). In 12 patients in whom therapy failed to eradicate the infection, the PGI was 87 ng/ml (35-128) before treatment and remained unchanged at 83 ng/ml (36-119) 1 month after treatment. In the group with successful eradication the median basal plasma gastrin was 43 ng/l (15-95) before treatment and fell to 30 ng/l (17-75) 1 month after treatment (p less than 0.003), but there was no change in the corresponding values in the group without eradication (55 ng/l; range, 25-120, and 45 ng/l; range, 5-175; p = 0.9). In conclusion, eradication of H. pylori results in a fall in PGI and plasma gastrin, and these changes are not due merely to the anti-H. pylori drugs themselves or to discontinuation of previous ulcer therapy.
十二指肠溃疡患者血清胃蛋白酶原I（PGI）浓度升高，幽门螺杆菌感染率也升高。我们研究了根除幽门螺杆菌感染对PGI的影响。在12例幽门螺杆菌被成功根除的十二指肠溃疡患者中，治疗前PGI中位数基础值为90 ng/ml（范围37 - 252），治疗1个月后降至74 ng/ml（28 - 197）（p<0.01）。在12例治疗未能根除感染的患者中，治疗前PGI为87 ng/ml（35 - 128），治疗1个月后维持在83 ng/ml（36 - 119）不变。在根除成功的组中，治疗前血浆胃泌素中位数基础值为43 ng/l（15 - 95），治疗1个月后降至30 ng/l（17 - 75）（p<0.003），但在未根除的组中相应值无变化（55 ng/l；范围25 - 120，以及45 ng/l；范围5 - 175；p = 0.9）。总之，根除幽门螺杆菌导致PGI和血浆胃泌素下降，这些变化不仅仅是由于抗幽门螺杆菌药物本身或先前溃疡治疗的中断所致。
