Remor E, Penedo F J, Shen B-J, Schneiderman N
Universidad Autónoma de Madrid, Spain.
AIDS Care. 2007 Feb;19(2):215-9. doi: 10.1080/09540120600645570.
This study assessed whether perceived stress as measured by the Perceived Stress Scale (PSS) was associated with a decline in CD4+ cell counts over a six-month period in 59 men and 41 women living with HIV-1. Participants underwent psychological and medical assessment at the study entry (baseline) and again at six months post-baseline. In a hierarchical regression model controlling for sociodemographic (e.g. age, gender, education, income) and disease-related variables (e.g. duration of antiretroviral treatment, antiretroviral treatment and adherence, CD4+ cell count and viral load), perceived stress was associated with the decline in CD4+ cell count over the six-month period. These findings suggest perceived psychosocial stress is associated with CD4+ cell count decline independent of sociodemographic factors and disease status among men and women on antiretroviral medication for HIV/AIDS.
本研究评估了在59名感染HIV-1的男性和41名感染HIV-1的女性中，通过感知压力量表（PSS）测量的感知压力是否与六个月内CD4+细胞计数下降有关。参与者在研究开始时（基线）以及基线后六个月再次接受心理和医学评估。在一个控制社会人口统计学（如年龄、性别、教育程度、收入）和疾病相关变量（如抗逆转录病毒治疗持续时间、抗逆转录病毒治疗及依从性、CD4+细胞计数和病毒载量）的分层回归模型中，感知压力与六个月内CD4+细胞计数下降有关。这些发现表明，在接受抗逆转录病毒药物治疗的HIV/AIDS男性和女性中，感知到的心理社会压力与CD4+细胞计数下降有关，且独立于社会人口统计学因素和疾病状态。
