Schnierle P, Sialm F, Seiler H G, Hering F, Rutishauser G
Institute for Inorganic Chemistry, University of Basle, Switzerland.
Urol Res. 1992;20(1):7-11. doi: 10.1007/BF00294327.
Certain important aspects of the urine oxalate tolerance test (OTT) have been revised. The stirring system has been changed and the test has been adapted to the kinetics of calcium oxalate precipitation. True equilibrium conditions are now ensured during the measurements. Furthermore, the endogenous oxalate concentration is determined and taken into consideration. As a result of these changes, the significance of the test results has greatly improved. The effects of the addition of small amounts of zinc on the precipitation of calcium oxalate have been used in a new variation of the OTT. This new test makes it possible to discriminate much faster and more simply between recurrent stone-formers and other subjects. Tamm-Horsfall protein (THP) has been tested for its effect on the precipitation of calcium oxalate by means of OTT. THP inhibits the precipitation of calcium oxalate, but THP of stone-formers has a diminished inhibitory activity. The inhibitory activity of this protein strongly depends on the method by which it is isolated.
尿草酸耐受性试验（OTT）的某些重要方面已得到修订。搅拌系统已更改，并且该试验已适应草酸钙沉淀的动力学。现在在测量过程中确保了真正的平衡条件。此外，内源性草酸盐浓度被测定并予以考虑。由于这些变化，试验结果的意义有了很大提高。在OTT的新变体中利用了添加少量锌对草酸钙沉淀的影响。这种新试验能够更快、更简单地区分复发性结石形成者和其他受试者。已通过OTT测试了Tamm-Horsfall蛋白（THP）对草酸钙沉淀的影响。THP抑制草酸钙沉淀，但结石形成者的THP抑制活性降低。这种蛋白质的抑制活性很大程度上取决于其分离方法。
