Rajakumar N, Hrycyshyn A W, Flumerfelt B A
Department of Anatomy, University of Western Ontario, London, Canada.
Anat Embryol (Berl). 1992;185(1):25-37. doi: 10.1007/BF00213598.
The organization of the afferent projections to the lateral reticular nucleus of the rat was investigated following placement of horseradish peroxidase-conjugated wheatgerm agglutinin into the red nucleus, fastigial nucleus, various levels of the spinal cord or the sensorimotor area of the cerebral cortex. The pattern of distribution of anterogradely labelled profiles visualized with tetramethylbenzidine revealed that the caudal three-fourths of the lateral reticular nucleus received a large, topographically organized projection from the entire length of the contralateral spinal cord. The lateral part of the rostral half of the lateral reticular nucleus received a small projection from the contralateral red nucleus, the dorsal part of the middle third of the nucleus received a diffuse projection from the contralateral fastigial nucleus, and the extreme rostromedial part of the nucleus received a sparse projection from the contralateral cerebral cortex. The dorsal part of the middle third of the lateral reticular nucleus also received a small projection from the ipsilateral cervical spinal cord. The distribution of afferent fibres from different levels of the spinal cord, red nucleus, and fastigial nucleus overlapped substantially in the middle third of the lateral reticular nucleus, whereas the cerebral cortical receiving area was separate. These data suggest that the middle third of the lateral reticular nucleus integrates spinal and supraspinal impulses to the cerebellum, while the rostral part of the nucleus is involved in a separate cerebral cortico-cerebellar pathway.
将辣根过氧化物酶结合的麦胚凝集素分别注入大鼠红核、顶核、脊髓不同节段或大脑皮质感觉运动区后，对大鼠外侧网状核传入投射的组织学结构进行了研究。用四甲基联苯胺显示的顺行标记轮廓的分布模式表明，外侧网状核尾侧四分之三接受来自对侧脊髓全长的大量、按拓扑结构组织的投射。外侧网状核嘴侧半部分的外侧接受来自对侧红核的少量投射，核中间三分之一的背侧接受来自对侧顶核的弥散投射，核最嘴内侧部分接受来自对侧大脑皮质的稀疏投射。外侧网状核中间三分之一的背侧也接受来自同侧颈髓的少量投射。来自脊髓不同节段、红核和顶核的传入纤维在外侧网状核中间三分之一处有大量重叠，而大脑皮质接受区是分开的。这些数据表明，外侧网状核中间三分之一整合了脊髓和脊髓上冲动至小脑，而该核嘴侧部分参与了一条独立的大脑皮质 - 小脑通路。
