Schlag Edward W, Sheu Sheh-Yi, Yang Dah-Yen, Selzle Heinrich L, Lin Sheng Hsien
Institut für Physikalische und Theoretische Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching, Germany.
Angew Chem Int Ed Engl. 2007;46(18):3196-210. doi: 10.1002/anie.200601623.
Biological systems often transport charges and reactive processes over substantial distances. Traditional models of chemical kinetics generally do not describe such extreme distal processes. In this Review, an atomistic model for a distal transport of information, which was specifically developed for peptides, is considered. Chemical reactivity is taken as the result of distal effects based on two-step bifunctional kinetics involving unique, very rapid motional properties of peptides in the subpicosecond regime. The bifunctional model suggests highly efficient transport of charge and reactivity in an isolated peptide over a substantial distance; conversely, a very low efficiency in a water environment was found. The model suggests ultrafast transport of charge and reactivity over substantial molecular distances in a peptide environment. Many such domains can be active in a protein.
生物系统常常在相当长的距离上传输电荷和进行反应过程。传统的化学动力学模型通常无法描述此类极端的远程过程。在本综述中，将考虑一种专门为肽开发的远程信息传输的原子模型。化学反应性被视为基于双功能两步动力学的远程效应的结果，该动力学涉及肽在亚皮秒范围内独特且非常快速的运动特性。双功能模型表明，电荷和反应性在孤立的肽中能在相当长的距离上高效传输；相反，在水环境中效率则非常低。该模型表明，在肽环境中，电荷和反应性能在相当大的分子距离上实现超快传输。许多这样的结构域在蛋白质中可能是活跃的。
