Department of Materials Engineering, Ben Gurion University of the Negev, Beer-Sheva, 84105, Israel.
Department of Electrical and Computer Engineering, UC San Diego, La Jolla, CA, 92093-0407, USA.
Adv Mater. 2018 Oct;30(41):e1707083. doi: 10.1002/adma.201707083. Epub 2018 Jul 10.
Noncovalent interactions are the main driving force in the folding of proteins into a 3D functional structure. Motivated by the wish to reveal the mechanisms of the associated self-assembly processes, scientists are focusing on studying self-assembly processes of short protein segments (peptides). While this research has led to major advances in the understanding of biological and pathological process, only in recent years has the applicative potential of the resulting self-assembled peptide assemblies started to be explored. Here, major advances in the development of biomimetic supramolecular peptide assemblies as coatings, gels, and as electroactive materials, are highlighted. The guiding lines for the design of helical peptides, β strand peptides, as well as surface binding monolayer-forming peptides that can be utilized for a specific function are highlighted. Examples of their applications in diverse immerging applications in, e.g., ecology, biomedicine, and electronics, are described. Taking into account that, in addition to extraordinary design flexibility, these materials are naturally biocompatible and ecologically friendly, and their production is cost effective, the emergence of devices incorporating these biomimetic materials in the market is envisioned in the near future.
非共价相互作用是蛋白质折叠成 3D 功能结构的主要驱动力。受揭示相关自组装过程机制的愿望的驱使，科学家们专注于研究短蛋白片段（肽）的自组装过程。虽然这项研究极大地促进了对生物和病理过程的理解，但直到最近，由此产生的自组装肽组装的应用潜力才开始被探索。在这里，重点介绍了作为涂层、凝胶和作为电活性材料的仿生超分子肽组装的主要进展。强调了设计螺旋肽、β 折叠肽以及可用于特定功能的表面结合单层形成肽的指导原则。描述了它们在生态学、生物医学和电子学等各种新兴应用中的应用实例。考虑到这些材料除了具有非凡的设计灵活性外，还具有天然的生物相容性和环境友好性，并且其生产成本效益高，预计在不久的将来，市场上将会出现包含这些仿生材料的设备。
