Molina Brooke S G, Pelham William E, Gnagy Elizabeth M, Thompson Amanda L, Marshal Michael P
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Alcohol Clin Exp Res. 2007 Apr;31(4):643-54. doi: 10.1111/j.1530-0277.2007.00349.x.
This study was designed to assess age specificity in the risk for heavy drinking and alcohol use disorder (AUD) among adolescents and young adults with Attention-Deficit/Hyperactivity Disorder (ADHD) diagnosed in childhood.
Children diagnosed with ADHD (n=364 probands) were interviewed an average of 8 years later in the Pittsburgh ADHD Longitudinal Study, either as adolescents (11-17 years old) or as young adults (18-28 years of age). Demographically similar age-matched participants without ADHD were recruited as adolescents (n=120) or as adults (n=120) for comparison with the probands. Alcohol involvement was assessed comprehensively to include measures of heavy drinking that are standard in alcoholism research and prognostic of later alcohol-related problems.
Results revealed age specificity in the association such that episodic heavy drinking (measured as 5+ drinks per occasion), drunkenness, DSM-IV AUD symptoms, and DSM-IV AUD were elevated among 15- to 17-year-old probands, but not among younger adolescents. Among young adults, drinking quantity and AUD were elevated among probands with antisocial personality disorder. Childhood predictors indexing antisocial behavior were also examined.
The age- specificity of these findings helps to explain prior inconsistencies across previous studies regarding risk for alcohol-related outcomes among children with ADHD.
本研究旨在评估童年期诊断为注意力缺陷多动障碍(ADHD)的青少年和青年中,重度饮酒及酒精使用障碍(AUD)风险的年龄特异性。
在匹兹堡ADHD纵向研究中,对诊断为ADHD的儿童(n = 364名先证者)平均在8年后进行访谈,访谈时他们要么处于青少年期(11 - 17岁),要么处于青年期(18 - 28岁)。招募了在人口统计学上与先证者年龄匹配、无ADHD的参与者作为青少年(n = 120)或成年人(n = 120),以与先证者进行比较。对酒精相关情况进行了全面评估,包括酗酒研究中的标准重度饮酒测量指标以及后续与酒精相关问题的预后指标。
结果显示该关联存在年龄特异性,即15至17岁的先证者中,发作性重度饮酒(定义为每次饮酒5杯及以上)、醉酒、DSM - IV酒精使用障碍症状及DSM - IV酒精使用障碍的发生率升高,而年龄较小的青少年中则未升高。在青年中,有反社会人格障碍的先证者饮酒量及酒精使用障碍发生率升高。还检查了指示反社会行为的童年预测因素。
这些发现的年龄特异性有助于解释先前关于ADHD儿童酒精相关后果风险的研究结果不一致的情况。