Boskabady Mohammad Hossein, Alizadeh Mansorah, Jahanbin Behnaz
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
Therapie. 2007 Jan-Feb;62(1):23-9. doi: 10.2515/therapie:2007007. Epub 2007 Mar 21.
Several therapeutic effects including anti-asthma and dyspnea have been described for the seeds of Carum copticum. In previous studies the relaxant and anticholinergic (functional antagonism) effects, histamine H(1) inhibitory and beta(2) stimulatory effects of Carum copticum have been demonstrated on guinea pig tracheal chains. In the present study, the bronchodilatory effect of boiled extract from Carum copticum in the airways of asthmatic patients was examined.
The bronchodilatory effects of 0.125 and 0.25 ml/kg of 10 g% boiled extract in comparison with 6 mg/kg theophylline and placebo were studied by measuring pulmonary function tests (PFTs) and specific airway conductance (sGaw). Pulmonary function tests were measured before administration and repeated 30, 60, 90, 120, 150 and 180 min after administration of the oral extract and theophylline.
The results showed that the boiled extract of Carum copticum caused significant increases in all PFT values, in most time intervals, (p<0.05 to p<0.001). However, the increase in most PFT values due to the both doses of boiled extract were significantly lower than those of theophylline in most time intervals (p<0.05 to p<0.001). The onset of brochodilatory effect of extract was similar to that of theophylline beginning 30 min, its maximum effect on PFTs (23 to 32% increase) was seen in 90-120 min and the effect of extract decline after 150 min following administration similar to the effect of theophylline. In addition the placebo did not cause any significant increase in PFT values.
In conclusion, the results of the present study showed that Carum copticum has a relatively bronchodilatory effect on asthmatic airways which was comparable with the effect of theophylline at concentrations used.
已报道藏茴香籽具有多种治疗作用，包括抗哮喘和缓解呼吸困难。在先前的研究中，已证实藏茴香对豚鼠气管链具有舒张和抗胆碱能（功能性拮抗）作用、组胺H(1)抑制作用及β(2)刺激作用。在本研究中，检测了藏茴香煮沸提取物对哮喘患者气道的舒张作用。
通过测量肺功能测试（PFT）和比气道传导率（sGaw），研究了0.125和0.25 ml/kg的10 g%煮沸提取物与6 mg/kg氨茶碱及安慰剂相比的支气管舒张作用。在口服提取物和氨茶碱给药前及给药后30、60、90、120、150和180分钟重复测量肺功能测试。
结果显示，在大多数时间间隔内，藏茴香煮沸提取物使所有PFT值显著增加（p<0.05至p<0.001）。然而，在大多数时间间隔内，由于两种剂量的煮沸提取物导致的大多数PFT值增加显著低于氨茶碱（p<0.05至p<0.001）。提取物的支气管舒张作用起效时间与氨茶碱相似，始于30分钟，其对PFT的最大作用（增加23%至32%）出现在90 - 120分钟，给药后150分钟后提取物的作用下降，与氨茶碱的作用相似。此外，安慰剂未使PFT值有任何显著增加。
总之，本研究结果表明，藏茴香对哮喘气道具有相对的支气管舒张作用，在所使用的浓度下与氨茶碱的作用相当。
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