Boskabady M H, Jandaghi P, Kiani S, Hasanzadeh L
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Post Code 91735, Mashhad, Iran.
J Ethnopharmacol. 2005 Feb 10;97(1):79-82. doi: 10.1016/j.jep.2004.10.016. Epub 2004 Dec 9.
Several therapeutic effects including anti-asthma and dyspnea have been described for the seeds of Carum copticum In previous studies the relaxant and anticholinergic (functional antagonism) effects, histamine (H(1)) inhibitory effect of Carum copticum have been demonstrated on guinea pig tracheal chains. In the present study the antitussive effect of this plant was evaluated. The antitussive effects of aerosols of two different concentrations of aqueous and macerated extracts and carvacrol, codeine, and saline were tested by counting the number of coughs produced due to aerosol of citric acid 10 min after exposing animals to aerosols of different solutions (for carvacrol n=5 and for other solutions n=6). The results showed significant reduction of cough number obtained in the presence of both concentrations of aqueous and macerated extracts and codeine (p<0.001 for extracts and p<0.01 for codeine). The cough number obtained in the presence of higher concentration of aqueous and macerated extracts was significantly less than those of lower concentrations (p<0.05 for both extracts). In addition the cough number obtained in the presence of both concentrations of aqueous and macerated extracts was significantly lower than that of codeine (p<0.05 to 0.001). However, carvacrol did not show any antitussive effect. These results indicated an antitussive effect of Carum copticum which was even greater than that of codeine at concentrations used. In addition the antitussive effect of Carum copticum was not due to its main constituent, carvacrol.
此前的研究已描述了藏茴香种子的多种治疗作用，包括抗哮喘和缓解呼吸困难。在先前的研究中，已证实藏茴香对豚鼠气管链具有舒张和抗胆碱能（功能性拮抗）作用以及组胺（H(1)）抑制作用。在本研究中，对该植物的镇咳作用进行了评估。通过计算动物暴露于不同溶液气雾剂（香芹酚组n = 5，其他溶液组n = 6）10分钟后因柠檬酸气雾剂引起的咳嗽次数，测试了两种不同浓度的水提取物、浸渍提取物、香芹酚、可待因和生理盐水气雾剂的镇咳作用。结果显示，两种浓度的水提取物和浸渍提取物以及可待因均能显著减少咳嗽次数（提取物p<0.001，可待因p<0.01）。高浓度水提取物和浸渍提取物引起的咳嗽次数显著少于低浓度提取物（两种提取物p<0.05）。此外，两种浓度的水提取物和浸渍提取物引起的咳嗽次数均显著低于可待因（p<0.05至0.001）。然而，香芹酚未显示出任何镇咳作用。这些结果表明藏茴香具有镇咳作用，在所使用的浓度下其镇咳作用甚至大于可待因。此外，藏茴香的镇咳作用并非因其主要成分香芹酚所致。
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