Lederer David J, Horn Evelyn M, Rosenzweig Erika B, Karmally Wahida, Jahnes Megan, Barst Robyn J, Kawut Steven M
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Pulm Pharmacol Ther. 2008;21(1):112-4. doi: 10.1016/j.pupt.2007.01.003. Epub 2007 Feb 12.
Serotonin (5-HT) has been implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We hypothesized that plasma 5-HT would be elevated in PAH related to associated conditions. We performed a prospective cohort study of 21 patients with PAH undergoing initial right heart catheterization and 6 healthy controls. Platelet-free plasma 5-HT levels were similar in patients with idiopathic PAH, PAH related to associated conditions, and healthy controls. Higher 5-HT levels correlated with increased six-minute walk distance (r=0.55, p=0.04). These data suggest that plasma 5-HT levels are normal in PAH. Plasma 5-HT may therefore not be a useful biomarker in this condition.
血清素（5-羟色胺，5-HT）与肺动脉高压（PAH）的发病机制有关。我们推测，与相关疾病相关的PAH患者血浆5-HT水平会升高。我们对21例接受初次右心导管检查的PAH患者和6名健康对照者进行了一项前瞻性队列研究。特发性PAH患者、与相关疾病相关的PAH患者和健康对照者的无血小板血浆5-HT水平相似。较高的5-HT水平与六分钟步行距离增加相关（r=0.55，p=0.04）。这些数据表明，PAH患者的血浆5-HT水平正常。因此，血浆5-HT在这种情况下可能不是一个有用的生物标志物。
