牛至、香芹酚和百里香酚对金黄色葡萄球菌和表皮葡萄球菌生物膜的影响。
Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms.
作者信息
Nostro Antonia, Roccaro Andrea Sudano, Bisignano Giuseppe, Marino Andreana, Cannatelli Maria A, Pizzimenti Francesco C, Cioni Pier Luigi, Procopio Francesca, Blanco Anna Rita
机构信息
Dipartimento Farmaco-Biologico, Facoltà di Farmacia, Università degli Studi di Messina, Villaggio Annunziata, 98168 Messina, Italy.
Direzione Ricerca, Sviluppo & Innovazione, SIFI SpA, Via Ercole Patti 36, Lavinaio, 95020 Catania, Italy.
出版信息
J Med Microbiol. 2007 Apr;56(Pt 4):519-523. doi: 10.1099/jmm.0.46804-0.
The aim of this study was to evaluate the effect of oregano essential oil, carvacrol and thymol on biofilm-grown Staphylococcus aureus and Staphylococcus epidermidis strains, as well as the effects of the oils on biofilm formation. For most of the S. aureus (n=6) and S. epidermidis (n=6) strains tested, the biofilm inhibitory concentration (0.125-0.500 %, v/v, for oregano, and 0.031-0.125 %, v/v, for carvacrol and thymol) and biofilm eradication concentration (0.25-1.0 %, v/v, for oregano and 0.125-0.500 %, v/v, for carvacrol and thymol) values were twofold or fourfold greater than the concentration required to inhibit planktonic growth. Subinhibitory concentrations of the oils attenuated biofilm formation of S. aureus and S. epidermidis strains on polystyrene microtitre plates.
本研究的目的是评估牛至精油、香芹酚和百里香酚对生物膜生长的金黄色葡萄球菌和表皮葡萄球菌菌株的影响，以及这些油对生物膜形成的影响。对于大多数测试的金黄色葡萄球菌（n = 6）和表皮葡萄球菌（n = 6）菌株，生物膜抑制浓度（牛至为0.125 - 0.500%，v/v；香芹酚和百里香酚为0.031 - 0.125%，v/v）和生物膜根除浓度（牛至为0.25 - 1.0%，v/v；香芹酚和百里香酚为0.125 - 0.500%，v/v）值比抑制浮游生长所需的浓度高两倍或四倍。这些油的亚抑制浓度减弱了金黄色葡萄球菌和表皮葡萄球菌菌株在聚苯乙烯微量滴定板上的生物膜形成。
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