基于使用真实组织样本进行 CT 校准的碳离子治疗计划中的靶区精度。
Range accuracy in carbon ion treatment planning based on CT-calibration with real tissue samples.
机构信息
Abteilung Biophysik, Gesellschaft für Schwerionenforschung, Planckstr. 1, 64291 Darmstadt, Germany.
出版信息
Radiat Oncol. 2007 Mar 23;2:14. doi: 10.1186/1748-717X-2-14.
BACKGROUND
The precision in carbon ion radiotherapy depends on the calibration of Hounsfield units (HU) as measured with computed tomography (CT) to water equivalence. This calibration can cause relevant differences between treatment planning and treatment delivery.
METHODS
Calibration data for several soft tissues were measured repeatedly to assess the accuracy of range calibration. Samples of fresh animal tissues including fat, brain, kidney, liver, and several muscle tissues were used. First, samples were CT scanned. Then carbon ion radiographic measurements were performed at several positions. Residual ranges behind the samples were compared to ranges in water.
RESULTS
Based on the measured data the accuracy of the current Hounsfield look-up table for range calibration of soft tissues is 0.2 +/- 1.2%. Accuracy in range calibration of 1% corresponds to approximately 1 mm carbon ion range control in 10 cm water equivalent depth which is comparable to typical treatment depths for head and neck tumors.
CONCLUSION
Carbon ion ranges can be controlled within approximately 1 mm in soft tissue for typical depths of head and neck treatments.
背景
碳离子放射治疗的精度取决于通过计算机断层扫描（CT）测量的与水等效的亨氏单位（HU）的校准。这种校准会在治疗计划和治疗实施之间造成相关差异。
方法
对几种软组织的校准数据进行了反复测量，以评估射程校准的准确性。使用了包括脂肪、脑、肾、肝和几种肌肉组织在内的新鲜动物组织样本。首先，对样本进行 CT 扫描。然后在几个位置进行碳离子射线照相测量。将样本后面的剩余射程与水中的射程进行比较。
结果
根据测量数据，目前软组织射程校准的亨氏查找表的精度为 0.2 +/- 1.2%。射程校准精度为 1%，相当于在 10 厘米水等效深度的头部和颈部肿瘤典型治疗深度中，大约 1 毫米的碳离子射程控制，这与典型的头部和颈部治疗深度相当。
结论
在头部和颈部治疗的典型深度下，碳离子射程在软组织中可以控制在大约 1 毫米以内。
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