脂筏与膜运输。

Lipid rafts and membrane traffic.

作者信息

Hanzal-Bayer Michael F, Hancock John F

机构信息

Institute for Molecular Bioscience, University of Queensland, St Lucia 4072, Australia.

出版信息

FEBS Lett. 2007 May 22;581(11):2098-104. doi: 10.1016/j.febslet.2007.03.019. Epub 2007 Mar 15.

DOI:10.1016/j.febslet.2007.03.019

PMID:17382322

Abstract

Membrane rafts are regions of increased lipid acyl chain order that differ in their lipid and protein composition from the surrounding membrane. By providing an additional level of compartmentalization they have been proposed to serve many functions in cellular signal transduction and trafficking. We will review their potential involvement in different forms of membrane traffic, explicitly excluding signalling, and discuss select aspects of the raft hypothesis in its current form.

摘要

膜筏是脂质酰基链有序性增加的区域，其脂质和蛋白质组成与周围膜不同。通过提供额外的区室化水平，它们被认为在细胞信号转导和运输中发挥多种功能。我们将综述它们在不同形式膜运输中的潜在参与情况（明确排除信号传导），并讨论当前形式的筏假说的某些方面。