Brandes R P
Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der J.W. Goethe-Universität, Frankfurt am Main, Germany.
Br J Pharmacol. 2007 Jun;151(3):303-4. doi: 10.1038/sj.bjp.0707229. Epub 2007 Mar 26.
Adipose tissue releases several hormones and autacoids and expansion of the adipose tissue and excessive obesity is a risk factor for hypertension. Perivascular adipose tissue, on the other hand, has been reported to lower the vascular tone through the release of a transferable, thermosensitive, non-lipid factor. In this issue of the British Journal of Pharmacology, Gao et al. (2007) report that a factor generated by the adipose tissue also stimulates the generation of NO by endothelium and that NO is the predominant mediator of adipose tissue-induced relaxation in endothelium-intact vessels.
脂肪组织会释放多种激素和自分泌物质，脂肪组织扩张和过度肥胖是高血压的一个危险因素。另一方面，据报道，血管周围脂肪组织通过释放一种可转移的、热敏的、非脂质因子来降低血管张力。在本期《英国药理学杂志》中，高等人（2007年）报告称，脂肪组织产生的一种因子也会刺激内皮细胞生成一氧化氮，并且一氧化氮是完整内皮血管中脂肪组织诱导舒张的主要介质。
