一种用于全局序列比较的简单方法。

A simple method for global sequence comparison.

作者信息

Pizzi E, Attimonelli M, Liuni S, Frontali C, Saccone C

机构信息

Centro Studi Mitocondri e Metabolismo Energetico CNR, Dipartimento di Biochimica e Biologia Molecolare, University of Bari, Italy.

出版信息

Nucleic Acids Res. 1992 Jan 11;20(1):131-6. doi: 10.1093/nar/20.1.131.

DOI:10.1093/nar/20.1.131

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC310336/

Abstract

A simple method of sequence comparison, based on a correlation analysis of oligonucleotide frequency distributions, is here shown to be a reliable test of overall sequence similarity. The method does not involve sequence alignment procedures and permits the rapid screening of large amounts of sequence data. It identifies those sequences which deserve more careful analysis of sequence similarity at the level of resolution of the single nucleotide. It uses observed quantities only and does not involve the adoption of any theoretical model.

摘要

一种基于寡核苷酸频率分布相关性分析的简单序列比较方法，被证明是一种可靠的整体序列相似性测试方法。该方法不涉及序列比对程序，可快速筛选大量序列数据。它能识别出那些值得在单核苷酸分辨率水平上更仔细分析序列相似性的序列。它仅使用观测值，不涉及任何理论模型的采用。

相似文献

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本文引用的文献

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Identification of common molecular subsequences.常见分子子序列的鉴定

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Improved tools for biological sequence comparison.用于生物序列比较的改进工具。

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