Bridot Jean-Luc, Faure Anne-Charlotte, Laurent Sophie, Rivière Charlotte, Billotey Claire, Hiba Bassem, Janier Marc, Josserand Véronique, Coll Jean-Luc, Elst Luce Vander, Muller Robert, Roux Stéphane, Perriat Pascal, Tillement Olivier
Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS-Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.
J Am Chem Soc. 2007 Apr 25;129(16):5076-84. doi: 10.1021/ja068356j. Epub 2007 Mar 31.
Luminescent hybrid nanoparticles with a paramagnetic Gd2O3 core were applied as contrast agents for both in vivo fluorescence and magnetic resonance imaging. These hybrid particles were obtained by encapsulating Gd2O3 cores within a polysiloxane shell which carries organic fluorophores and carboxylated PEG covalently tethered to the inorganic network. Longitudinal proton relaxivities of these particles are higher than the positive contrast agents like Gd-DOTA which are commonly used for clinical magnetic resonance imaging. Moreover these particles can be followed up by fluorescence imaging. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs and liver.
具有顺磁性Gd2O3核的发光杂化纳米粒子被用作体内荧光和磁共振成像的造影剂。这些杂化粒子是通过将Gd2O3核包裹在聚硅氧烷壳内而获得的，聚硅氧烷壳带有有机荧光团和与无机网络共价连接的羧基化聚乙二醇。这些粒子的纵向质子弛豫率高于常用于临床磁共振成像的阳性造影剂如钆喷酸葡胺。此外，这些粒子可以通过荧光成像进行追踪。这项研究表明，这些适用于双模态成像的粒子可在血管中自由循环，而不会在肺和肝脏中产生不良积聚。
