Alric Christophe, Taleb Jacqueline, Le Duc Géraldine, Mandon Céline, Billotey Claire, Le Meur-Herland Alice, Brochard Thierry, Vocanson Francis, Janier Marc, Perriat Pascal, Roux Stéphane, Tillement Olivier
Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS-Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.
J Am Chem Soc. 2008 May 7;130(18):5908-15. doi: 10.1021/ja078176p. Epub 2008 Apr 12.
Functionalized gold nanoparticles were applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. These particles were obtained by encapsulating gold cores within a multilayered organic shell which is composed of gadolinium chelates bound to each other through disulfide bonds. The contrast enhancement in MRI stems from the presence of gadolinium ions which are entrapped in the organic shell, whereas the gold core provides a strong X-ray absorption. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in the lungs, spleen, and liver.
功能化金纳米颗粒被用作体内X射线和磁共振成像的造影剂。这些颗粒是通过将金核包裹在多层有机壳中获得的，该有机壳由通过二硫键相互结合的钆螯合物组成。MRI中的造影增强源于包裹在有机壳中的钆离子的存在，而金核提供强烈的X射线吸收。这项研究表明，这些适用于双模态成像的颗粒可在血管中自由循环，而不会在肺、脾和肝脏中产生不良积累。
