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碘-125治疗脉络膜黑色素瘤

Radiotherapy of choroidal melanoma with iodine-125.

作者信息

Packer S, Rotman M

出版信息

Ophthalmology. 1980 Jun;87(6):582-90. doi: 10.1016/s0161-6420(80)35194-4.

DOI:10.1016/s0161-6420(80)35194-4
PMID:7413147
Abstract

The low-energy radioactive source iodine-125 is ideal for the irradiation of an intraocular tumor tumor such as a choroidal melanoma. The energy (28 kev) of iodine-125 should be sufficient to allow sterilization of tumors as high as 10 mm. However, shielding of 18-kev photons can be achieved with thin metal (eg, gold) plaques. Thse eye plaques can be individually designed for each eye tumor, depending on its size, shape, and location. This paper deals with the basic considerations and preliminary observations that have lead us to the adoption of iodine-125 as the sole source for the radiation treatment of all intraocular tumors.

摘要

低能量放射源碘-125是眼内肿瘤(如脉络膜黑色素瘤)照射的理想选择。碘-125的能量(28千电子伏特)应足以对高达10毫米的肿瘤进行杀菌。然而,18千电子伏特光子的屏蔽可以用薄金属(如金)板来实现。这些眼敷贴可以根据每个眼肿瘤的大小、形状和位置进行单独设计。本文论述了一些基本考量和初步观察结果,这些促使我们采用碘-125作为所有眼内肿瘤放射治疗的唯一放射源。

相似文献

1
Radiotherapy of choroidal melanoma with iodine-125.碘-125治疗脉络膜黑色素瘤
Ophthalmology. 1980 Jun;87(6):582-90. doi: 10.1016/s0161-6420(80)35194-4.
2
Alternative dose for choroidal melanoma treated with an iodine-125 radioactive plaque: a single-institution retrospective study.脉络膜黑色素瘤放射性碘 125 贴治疗的替代剂量:单机构回顾性研究。
Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):844-8. doi: 10.1016/j.ijrobp.2009.08.059. Epub 2010 Feb 19.
3
Radiotherapy of choroidal melanoma with iodine 125.用碘125对脉络膜黑色素瘤进行放射治疗。
Int Ophthalmol Clin. 1980 Summer;20(2):135-42.
4
Irradiation of choroidal melanoma with iodine 125 ophthalmic plaque.用碘125眼贴照射脉络膜黑色素瘤。
Arch Ophthalmol. 1980 Aug;98(8):1453-7. doi: 10.1001/archopht.1980.01020040305019.
5
Improved iodine-125 plaque design in the treatment of choroidal malignant melanoma.用于脉络膜恶性黑色素瘤治疗的改良碘-125敷贴器设计
Br J Ophthalmol. 1992 Feb;76(2):91-4. doi: 10.1136/bjo.76.2.91.
6
Iodine-125 irradiation of choroidal melanoma. Clinical experience.
Ophthalmology. 1984 Dec;91(12):1700-8. doi: 10.1016/s0161-6420(84)34089-1.
7
Plaque radiotherapy for juxtapapillary choroidal melanoma. Visual acuity and survival outcome.视乳头旁脉络膜黑色素瘤的斑块放射治疗。视力和生存结果。
Arch Ophthalmol. 1996 Nov;114(11):1357-65. doi: 10.1001/archopht.1996.01100140557006.
8
Radioactive iodine-125 as a therapeutic radiation source for management of intraocular tumors.放射性碘-125作为治疗眼内肿瘤的放射源。
Trans Am Ophthalmol Soc. 1981;79:294-306.
9
Outcomes of choroidal melanomas treated with eye physics: a 20-year review.眼科学治疗脉络膜黑色素瘤的结果:20 年回顾。
JAMA Ophthalmol. 2013 Nov;131(11):1435-42. doi: 10.1001/jamaophthalmol.2013.4422.
10
Preliminary observations regarding the use of iodine-125 in the management of choroidal melanoma.关于碘-125在脉络膜黑色素瘤治疗中的初步观察。
Trans Ophthalmol Soc U K (1962). 1983;103 ( Pt 2):155-60.

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3
A study comparing baseline and best-corrected visual acuity after iodine-125 episcleral brachytherapy in uveal melanoma.
一项关于葡萄膜黑色素瘤患者接受碘-125巩膜近距离放射治疗后基线视力与最佳矫正视力对比的研究。
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Radiation Retinopathy: Detection and Management Strategies.放射性视网膜病变:检测与管理策略
Clin Ophthalmol. 2021 Sep 8;15:3797-3809. doi: 10.2147/OPTH.S219268. eCollection 2021.
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Mortality after deferral of treatment or no treatment for choroidal melanoma.脉络膜黑色素瘤延迟治疗或不治疗的死亡率。
Indian J Ophthalmol. 2018 Oct;66(10):1395-1400. doi: 10.4103/ijo.IJO_1499_18.
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Visual outcome after posterior uveal melanoma episcleral brachytherapy including radiobiological doses.后葡萄膜黑色素瘤巩膜近距离放射治疗后的视觉结果,包括放射生物学剂量。
J Contemp Brachytherapy. 2018 Apr;10(2):123-131. doi: 10.5114/jcb.2018.75597. Epub 2018 Apr 30.
7
Iodine-125 Brachytherapy for Uveal Melanoma: A Systematic Review of Radiation Dose.碘-125近距离放射治疗葡萄膜黑色素瘤:辐射剂量的系统评价
Ocul Oncol Pathol. 2017 Sep;3(3):193-198. doi: 10.1159/000455872. Epub 2017 Feb 8.
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Clinical Outcomes of Proton Beam Therapy for Choroidal Melanoma at a Single Institute in Korea.韩国单机构质子束治疗脉络膜黑色素瘤的临床结果。
Cancer Res Treat. 2018 Apr;50(2):335-344. doi: 10.4143/crt.2017.070. Epub 2017 Apr 19.
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The retina dose-area histogram: a metric for quantitatively comparing rival eye plaque treatment options.视网膜剂量-面积直方图:一种用于定量比较竞争性眼敷贴治疗方案的指标。
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In vivo high-frequency, contrast-enhanced ultrasonography of uveal melanoma in mice: imaging features and histopathologic correlations.体内高频对比增强超声在小鼠葡萄膜黑色素瘤中的应用:影像学特征与组织病理学相关性。
Invest Ophthalmol Vis Sci. 2011 Apr 1;52(5):2662-8. doi: 10.1167/iovs.10-6794. Print 2011 Apr.