Diallo A, Minet C, Le Goff C, Berhe G, Albina E, Libeau G, Barrett T
Animal Production Unit, FAO/IAEA Agriculture and Biotechnology Laboratory, Agency's Laboratories, Wagramerstrasse 5, P.O. Box 100, A-1400 Vienna, Austria.
Vaccine. 2007 Jul 26;25(30):5591-7. doi: 10.1016/j.vaccine.2007.02.013. Epub 2007 Feb 26.
Peste des petits ruminants (PPR) is a highly contagious animal disease caused by a virus in the genus Morbillivirus, family Paramyxoviridae. This infection is responsible for high morbidity and mortality in sheep and goats and in some small wild ruminant species. The huge number of small ruminants, which are reared in the endemic areas makes PPR a serious disease threatening the livelihood of poor farmers. Taking advantage of the closely relationship between rinderpest and PPR viruses, the attenuated rinderpest vaccine was used in the control of PPR. It is now replaced by the homologous attenuated PPR vaccine. Unfortunately, animals that have received this vaccine cannot be distinguished serologically from infected animals. With the advent of DNA recombinant technology, efforts are being made to develop effective PPR marker vaccines to enable such differentiation and which would allow countries to implement both vaccination and disease surveillance programmes at the same time.
小反刍兽疫（PPR）是由副粘病毒科麻疹病毒属中的一种病毒引起的一种高度传染性动物疾病。这种感染导致绵羊、山羊以及一些小型野生反刍动物出现高发病率和高死亡率。在流行地区饲养的大量小反刍动物使得小反刍兽疫成为一种严重威胁贫困农民生计的疾病。利用牛瘟病毒与小反刍兽疫病毒之间的密切关系，减毒牛瘟疫苗曾被用于控制小反刍兽疫。现在它已被同源减毒小反刍兽疫疫苗所取代。不幸的是，接种了这种疫苗的动物在血清学上无法与感染动物区分开来。随着DNA重组技术的出现，人们正在努力开发有效的小反刍兽疫标记疫苗，以实现这种区分，并使各国能够同时实施疫苗接种和疾病监测计划。
