Lawry Monica
Nail Disease Clinic, UC Davis, Department of Dermatology, Sacramento, California 95825, USA.
Dermatol Ther. 2007 Jan-Feb;20(1):60-7. doi: 10.1111/j.1529-8019.2007.00112.x.
Nail psoriasis affects 50% of psoriasis patients and in many cases causes impairment of manual dexterity, pain, and psychologic stress. Despite the fact that about 80% of psoriatic arthritis patients have nail involvement, patients rarely receive treatment for nail disease. Because of great difficulty in drug delivery to site of action and significant toxicities of most conventional systemic therapies, treatment of nail psoriasis can be very challenging. Biological therapy for psoriasis and psoriatic arthritis is now widely used, and early evidence indicates it may have significant benefit for some patients with psoriatic nail disease. This article reviews the clinical manifestations of nail psoriasis and discusses how to use specific biologic therapies that may provide significant new treatment options for this challenging disease.
甲银屑病影响50%的银屑病患者，在许多情况下会导致手部灵活性受损、疼痛和心理压力。尽管约80%的银屑病关节炎患者有甲受累情况，但患者很少接受甲病治疗。由于药物输送到作用部位存在很大困难，且大多数传统全身疗法有显著毒性，甲银屑病的治疗极具挑战性。银屑病和银屑病关节炎的生物疗法目前已广泛应用，早期证据表明其可能对一些银屑病甲病患者有显著益处。本文综述了甲银屑病的临床表现，并讨论了如何使用特定生物疗法，这些疗法可能为这种具有挑战性的疾病提供重要的新治疗选择。
