Garbers Luiz Eduardo Fabricio de Melo, Slongo Helena, Fabricio Lincoln Helder Zambaldi, Schmitt Juliano Vilaverde, Bonalumi Aguinaldo
Faculdade Evangélica do Paraná (Fepar) - Curitiba (PR), Brazil.
Universidade Estadual Paulista "Júlio de Mesquita Filho" (Unesp) - São Paulo (SP), Brazil.
An Bras Dermatol. 2016 May-Jun;91(3):300-5. doi: 10.1590/abd1806-4841.20164296.
Psoriasis is a chronic inflammatory skin disease that often progresses with nail alterations. It is suspected that there is a correlation between nail psoriasis and enthesitis of the distal interphalangeal joint, seeming to serve as a predictor.
To analyze the profile of patients with nail psoriasis and correlate the presence of nail alterations with psoriatic arthritis, quality of life, extent of psoriasis and the histopathology of the nail.
An observational cross-sectional study with 40 patients with a diagnosis of psoriasis and without systemic treatment. The patient profile was researched, including quality of life and evaluated for the presence of psoriatic arthritis. The severity of the skin psoriasis and the presence of nail lesions were evaluated. Nail fragments were collected and analyzed through clipping. It obtained 100% of positivity for psoriasis in the histopathology exam of the nail plate.
Of the 40 patients, 65% were diagnosed with nail psoriasis. Suggestive findings of psoriatic arthritis in hands were present in 33%, being more frequent in those with nail alteration (p = 0.01). In 92.3% of patients diagnosed with psoriatic arthritis in the hands there was some nail injury. The most frequent injuries were pitting and onycholysis.
Patients with nail psoriasis are usually men, with worse quality of life and higher chance of psoriatic arthritis. The correlation between the nail involvement of psoriasis and psoriatic arthritis in hands confirms the association between these two forms. The clinical diagnosis of nail psoriasis did not correlate with the histological diagnosis.
银屑病是一种慢性炎症性皮肤病，常伴有指甲改变。怀疑指甲银屑病与远端指间关节附着点炎之间存在关联，似乎可作为一种预测指标。
分析指甲银屑病患者的特征，并将指甲改变的存在与银屑病关节炎、生活质量、银屑病范围及指甲组织病理学相关联。
对40例诊断为银屑病且未接受系统治疗的患者进行观察性横断面研究。研究患者特征，包括生活质量，并评估银屑病关节炎的存在情况。评估皮肤银屑病的严重程度及指甲病变的存在情况。通过剪取收集指甲碎片并进行分析。在甲板组织病理学检查中银屑病的阳性率达100%。
40例患者中，65%被诊断为指甲银屑病。手部银屑病关节炎的提示性表现见于33%的患者，在有指甲改变的患者中更常见（p = 0.01）。在手部诊断为银屑病关节炎的患者中，92.3%存在某种指甲损伤。最常见的损伤是点状凹陷和甲剥离。
指甲银屑病患者通常为男性，生活质量较差，患银屑病关节炎的几率更高。银屑病的指甲受累与手部银屑病关节炎之间的关联证实了这两种形式之间的联系。指甲银屑病的临床诊断与组织学诊断不相关。
