Perez-Pastene Carolina, Graumann Rebecca, Díaz-Grez Fernando, Miranda Marcelo, Venegas Pablo, Godoy Osvaldo Trujillo, Layson Luis, Villagra Roque, Matamala Jose Manuel, Herrera Luisa, Segura-Aguilar Juan
Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Casilla 70000, Santiago-7, Chile.
Neurosci Lett. 2007 May 17;418(2):181-5. doi: 10.1016/j.neulet.2007.03.024. Epub 2007 Mar 14.
We have studied the association of a null mutation of Glutathione Transferase M1 (GST M10/0) with Parkinson's disease (MIM 168600) in a Chilean population with a strong Amerindian genetic component. We determined the genotype in 349 patients with idiopathic Parkinson's disease (174 female and 175 male; 66.84+/-10.7 years of age), and compared that to 611 controls (457 female and 254 male; 62+/-13.4 years of age). A significant association of the null mutation in GST M1 with Parkinson's disease was found (p=0.021), and the association was strongest in the earlier age range. An association of GSTM10/0 with Parkinson's disease supports the hypothesis that Glutathione Transferase M1 plays a role in protecting astrocytes against toxic dopamine oxidative metabolism, and most likely by preventing toxic one-electron reduction of aminochrome.
我们在一个具有强烈美洲印第安人遗传成分的智利人群中，研究了谷胱甘肽转移酶M1（GST M10/0）的无效突变与帕金森病（MIM 168600）之间的关联。我们确定了349例特发性帕金森病患者（174例女性和175例男性；年龄66.84±10.7岁）的基因型，并将其与611名对照者（457例女性和254例男性；年龄62±13.4岁）进行比较。发现GST M1中的无效突变与帕金森病存在显著关联（p = 0.021），且该关联在较早年龄范围内最为明显。GSTM10/0与帕金森病的关联支持了这样一种假说，即谷胱甘肽转移酶M1在保护星形胶质细胞免受有毒多巴胺氧化代谢影响方面发挥作用，很可能是通过防止氨基chrome的有毒单电子还原实现的。
