Maurya Pawan Kumar, Kumar Prabhanshu, Chandra Pranjal
Pawan Kumar Maurya, Interdisciplinary Laboratory of Clinical Neuroscience (LINC), Department of Psychiatry, Federal University of São Paulo, São Paulo 04039-032, Brazil.
World J Methodol. 2015 Dec 26;5(4):216-22. doi: 10.5662/wjm.v5.i4.216.
Despite more than 300 theories to explain the aging process, oxidative stress theory offers the best mechanism to explain aging and age related disorders. Several studies has shown the importance of oxidative stress during aging. PubMed, Science Direct and Springer online data bases are taken into consideration to write this mini-review. Human erythrocytes are most abundant and specialized cells in the body. Erythrocytes were extensively studied due to their metabolism and gas transport functions. Recent studies on erythrocytes have provided us detailed information of cell membrane and its structural organization that may help in studying the aging and age associated changes. The susceptibility of an organism is associated with the antioxidant potential of the body. Erythrocytes have potent antioxidant protection consisting of enzymatic and non-enzymatic pathways that counteract with reactive oxygen species, thus maintaining the redox regulation in the body. The non-enzymatic and enzymatic antioxidants and other biomarkers associated with erythrocyte membrane transport functions are the main content of this review. Biomarkers of oxidative stress in erythrocytes and its membrane were taken into the consideration during human aging that will be the main subject of this mini- review.
尽管有300多种理论来解释衰老过程，但氧化应激理论为解释衰老及与年龄相关的疾病提供了最佳机制。多项研究表明了氧化应激在衰老过程中的重要性。撰写本综述时参考了PubMed、Science Direct和Springer在线数据库。人类红细胞是体内数量最多且特殊的细胞。由于其代谢和气体运输功能，红细胞得到了广泛研究。近期对红细胞的研究为我们提供了关于细胞膜及其结构组织的详细信息，这可能有助于研究衰老及与年龄相关的变化。生物体的易感性与身体的抗氧化潜力有关。红细胞具有强大的抗氧化保护机制，包括酶促和非酶促途径，可与活性氧相互作用，从而维持体内的氧化还原调节。与红细胞膜运输功能相关的非酶促和酶促抗氧化剂及其他生物标志物是本综述的主要内容。人类衰老过程中红细胞及其膜内氧化应激的生物标志物是本综述的主要主题。
