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["高效抗逆转录病毒治疗(HAART)时代HIV阳性患者中的乙肝病毒(HBV)与丙肝病毒(HCV)合并感染:新挑战"]

[HBV and HCV co-infections in HIV positive patients in the "HAART era": new challenges].

作者信息

Laufer Natalia L, Quarleri Jorge F, Bouzas Maria B, Perez Hector M, Salomon Horacio, Cahn Pedro E

机构信息

Servicio de Infectología, Hospital Juan A. Fernández Buenos Aires.

出版信息

Medicina (B Aires). 2007;67(1):82-91.

PMID:17408028
Abstract

Co-infections with HIV and HCV/HBV are frequently found due to the similar routes of transmission (sexual, parenteral and vertical). Since the introduction of highly active antiretroviral therapy (HAART) there has been a notably decrease in patients morbidity and mortality, nevertheless with the prolonged survival, many of these patients are at risk of developing chronic complication, secondary to the infection of hepatotropic viruses. End stage liver disease is one of the main causes of morbid-mortality among HIV patients in developed countries. Nowadays there are new available therapies, diagnostic and follow up techniques for HBV and HCV, what provides a better control of both co-infections.

摘要

由于HIV与HCV/HBV的传播途径相似(性传播、经肠外途径传播和母婴垂直传播),因此经常发现合并感染情况。自从采用高效抗逆转录病毒疗法(HAART)以来,患者的发病率和死亡率显著下降,然而,随着生存期延长,许多此类患者有发生慢性并发症的风险,这些并发症继发于嗜肝病毒感染。终末期肝病是发达国家HIV患者发病和死亡的主要原因之一。如今,有了针对HBV和HCV的新型有效疗法、诊断和随访技术,这使得对两种合并感染都能实现更好的控制。

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